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ACTIVE NOT RECRUITING Phase 1

A Study of Sovilnesib in Subjects With Ovarian Cancer

NCT06084416 · View on ClinicalTrials.gov ↗

Study Summary

This is a randomized, phase 1b study to assess the safety, tolerability, pharmacokinetics (PK), and efficacy of sovilnesib at different dose levels to establish the Recommended Phase 2 Dose (RP2D) of sovilnesib in subjects with high grade serous ovarian cancer (HGSOC).

Interventions

  • DRUG Sovilnesib

Study Locations (13)

California

  • UCLA — Los Angeles
  • Hoag Memorial Hospital — Newport Beach

New York

  • Roswell Park Comprehensive Cancer Center — Buffalo
  • Icahn School of Medicine at Mount Sinai — New York

Alabama

  • The University of Alabama at Birmingham — Birmingham

Arkansas

  • University of Arkansas for Medical Sciences — Little Rock

Georgia

  • Georgia Cancer Center Augusta University — Atlanta

Maryland

  • Johns Hopkins Hospital — Baltimore

Massachusetts

  • Dana Farber Cancer Institute — Boston

Michigan

  • Corewell Health — Grand Rapids

Trial Details

FieldValue
Enrollment Target 120 participants
Start Date 2024-04-04
Est. Completion 2026-04
Phase Phase 1

Sponsor

Volastra Therapeutics

2 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06084416

The ClinicalTrials.gov registry entry for NCT06084416 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 120 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Volastra Therapeutics, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 4 conditions, with Fallopian Tube Cancer appearing as the primary indexed condition, and to 1 intervention — of which Sovilnesib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06084416 reports 13 study locations spanning 11 distinct geographic areas — top geographies include California, New York, Alabama. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06084416 about?

NCT06084416 is a clinical study titled "A Study of Sovilnesib in Subjects With Ovarian Cancer". This is a randomized, phase 1b study to assess the safety, tolerability, pharmacokinetics (PK), and efficacy of sovilnesib at different dose levels to establish the Recommended Phase 2 Dose (RP2D) of sovilnesib in subjects with high grade serous ovarian cancer (HGSOC).

What is the current status of trial NCT06084416?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 120 participants. The study started on 2024-04-04. Estimated completion is 2026-04.

What conditions does trial NCT06084416 study?

This clinical trial studies the following conditions: Fallopian Tube Cancer, Primary Peritoneal Carcinoma, High Grade Serous Adenocarcinoma of Ovary, Chromosomal Instability. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06084416?

The interventions under investigation include: Sovilnesib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06084416?

This trial is sponsored by Volastra Therapeutics, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06084416 being conducted?

This trial has 13 study locations across Alabama, Arkansas, California, Georgia, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial