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NCT06071728 · ClinicalTrials.gov registry record · NA
Restoring Glycocalyx Thickness in Older Adults to Improve Vascular Function
A NA study, sponsored by University of Iowa.
- Completed
- Registry status
- NA
- Development phase
- 24
- Enrollment target
NCT06071728 is a NA study that has completed, run by University of Iowa. The registered enrollment target is 24 participants.
The verdict
NCT06071728, a NA study, has completed, sponsored by University of Iowa.
- COMPLETED
- Registry status
- NA
- Development phase
- 24 participants
- Enrollment target
Study Summary
The glycocalyx serves as the interface between flowing blood and endothelial cells, the single cell layer that lines blood vessels, and is crucial for normal blood vessel function. Specifically, the glycocalyx protects endothelial cells from oxidative stress and inflammation and enables blood vessel dilation, which is largely dependent on the bioavailability of the vasodilatory molecule nitric oxide. Importantly, glycocalyx thickness decreases with age and is predictive of major adverse cardiovascular events in older adults free of cardiovascular disease. Therefore, interventions aimed at restoring glycocalyx thickness in older adults are desperately needed. Endocalyx Pro is a commercially available glycocalyx precursor supplement, manufactured by Microvascular Health Solutions, designed to 1) repair a damaged glycocalyx, 2) protect against damage to the glycocalyx, and 3) synthesize new glycocalyx components, and has been used to increase glycocalyx thickness in humans. However, no study has tested if glycocalyx thickness restores glycocalyx thickness in older adults and improves blood vessel function. Thus, the purpose of this investigation is to determine if 12-weeks of Endocalyx Pro supplementation alters glycocalyx thickness and blood vessel function in older adults. The investigators will use a camera placed under the tongue to determine glycocalyx thickness. The investigators will measure blood vessel function by measuring brachial artery dilation with ultrasound and arterial stiffness using pressure probes placed on the carotid and femoral artery.
Interventions
- DIETARY_SUPPLEMENT Endocalyx Pro (Microvascular Health Solutions, US Patent Number: 9943572)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2022-10-10 |
| Est. Completion | 2024-01-31 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06071728
The ClinicalTrials.gov registry entry for NCT06071728 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 24 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Iowa, which has 228 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Endocalyx Pro (Microvascular Health Solutions, US Patent Number: 9943572) is the first listed.
NCT06071728 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT06071728 about?
NCT06071728 is a clinical study titled "Restoring Glycocalyx Thickness in Older Adults to Improve Vascular Function". The glycocalyx serves as the interface between flowing blood and endothelial cells, the single cell layer that lines blood vessels, and is crucial for normal blood vessel function. Specifically, the glycocalyx protects endothelial cells from oxidative stress and inflammation and enables blood vessel...
What is the current status of trial NCT06071728?
This trial is currently completed. It is a NA study. The enrollment target is 24 participants. The study started on 2022-10-10. Estimated completion is 2024-01-31.
What interventions are being tested in trial NCT06071728?
The interventions under investigation include: Endocalyx Pro (Microvascular Health Solutions, US Patent Number: 9943572) (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT06071728?
This trial is sponsored by University of Iowa, which has 228 total clinical trials registered on ClinicalTrials.gov.
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