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NCT06054295 · ClinicalTrials.gov registry record
Somatic Mosaicism in Twins Discordant for Childhood Cancer
A clinical trial of Central Nervous System Tumor and Somatic Mutation, sponsored by Children's Oncology Group.
- Recruiting
- Registry status
- 50
- Enrollment target
- 1
- Study location
NCT06054295: Recruiting study of Central Nervous System Tumor and Somatic Mutation, sponsored by Children's Oncology Group.
NCT06054295 is a study of Central Nervous System Tumor and Somatic Mutation that is actively recruiting participants, run by Children's Oncology Group. The registered enrollment target is 50 participants, below the 172-participant average among 5 other Central Nervous System Tumor trials with a reported enrollment target (71% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06054295, a study of Central Nervous System Tumor and Somatic Mutation, is actively recruiting participants, sponsored by Children's Oncology Group.
- RECRUITING
- Registry status
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
Somatic mosaicism in cancer associated genes is one potential explanation for discordance in childhood cancer that has not been fully explored to date. This pilot study will focus on twins with central nervous system (CNS) tumors who are identified through the Children's Oncology Group's Project: EveryChild (PEC) registry or volunteer.
Primary Outcome
Sequence blood and saliva DNA samples from 25 MZ twin pairs using a panel of 94 known cancer associated genes.
Conditions Studied
Interventions
- OTHER Questionnaire Administration
- OTHER Biospecimen collection
Study Locations (1)
Minnesota
- University of Minnesota - Minneapolis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2024-06-03 |
| Est. Completion | 2027-06-30 |
What NCT06054295 shows while recruiting
NCT06054295 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 172-participant average among 5 other Central Nervous System Tumor trials with a reported enrollment target (71% lower).
The record links to 4 conditions, with Central Nervous System Tumor appearing as the primary indexed condition, and to 2 interventions - of which Questionnaire Administration is the first listed.
NCT06054295 reports a single indexed study location in Minnesota.
Frequently Asked Questions
What is clinical trial NCT06054295 about?
NCT06054295 is a clinical study titled "Somatic Mosaicism in Twins Discordant for Childhood Cancer". Somatic mosaicism in cancer associated genes is one potential explanation for discordance in childhood cancer that has not been fully explored to date. This pilot study will focus on twins with central nervous system (CNS) tumors who are identified through the Children's Oncology Group's Project: Ev...
What is the current status of trial NCT06054295?
This trial is currently recruiting. The enrollment target is 50 participants. The study started on 2024-06-03. Estimated completion is 2027-06-30.
What conditions does trial NCT06054295 study?
This clinical trial studies the following conditions: Central Nervous System Tumor, Somatic Mutation, Pediatric Central Nervous System Tumor, Discordant Twin.
What interventions are being tested in trial NCT06054295?
The interventions under investigation include: Questionnaire Administration (OTHER), Biospecimen collection (OTHER).
Who is sponsoring clinical trial NCT06054295?
This trial is sponsored by Children's Oncology Group, which has 342 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06054295 being conducted?
This trial has 1 study location across Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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