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Global Multicenter Registry on Transcatheter TRIcuspid Valve RePLACEment
NCT06033274 · View on ClinicalTrials.gov ↗
Study Summary
The field of transcatheter tricuspid valve replacement (TTVR) is rapidly emerging and data on this topic are scarce. Particularly, little is known about which patients are at greatest risk of procedural complications, such as the timing and onset of conduction disturbances necessitating permanent pacemaker implantation, and how such patients are managed. On this background, the TRIPLACE Registry - an investigator-initiated global multicenter registry - is aimed at better understanding the safety and efficacy of orthotopic TTVR.
Conditions Studied
Interventions
- DEVICE Transcatheter Tricuspid Valve Replacement
Study Locations (20)
Other
- Rigshospitalet, Copenhagen University Hospital — Copenhagen
- Centre Hospitalier Universitaire de Lille — Lille
- Clinique Pasteur Toulouse — Toulouse
- Heart and Diabetes Centre, North Rhine-Westphalia (NRW), Ruhr-University — Bad Oeynhausen
- Heart Center Cologne, University of Cologne — Cologne
- Cardiovascular Center (CVC) Frankfurt, Division of Cardiology — Frankfurt
- University Heart and Vascular Center, Department of Cardiology — Hamburg
- University Heart Center, Schleswig-Holstein University — Lübeck
- Medical Clinic and Polyclinic, University Hospital of Munich (LMU Klinikum) — Munich
- San Raffaele University Hospital — Milan
- Centro Cardiologico Monzino IRCCS — Milan
New York
- Columbia University Irving Medical Center — New York
- Montefiore Medical Center — The Bronx
Arizona
- Arizona Heart Hospital (Biltmore Cardiology) — Phoenix
Ohio
- Cleveland Clinic — Cleveland
Oregon
- Oregon Health & Science University — Portland
British Columbia
- St. Paul's Hospital — Vancouver
Ontario
- St Michael's Hospital, University of Toronto — Toronto
Quebec
- Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada — Québec
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 800 participants |
| Start Date | 2023-10-05 |
| Est. Completion | 2026-08 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06033274
The ClinicalTrials.gov registry entry for NCT06033274 describes a study currently listed as recruiting. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 800 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Montefiore Medical Center, which has 280 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Tricuspid Regurgitation appearing as the primary indexed condition, and to 1 intervention — of which Transcatheter Tricuspid Valve Replacement is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06033274 reports 20 study locations spanning 9 distinct geographic areas — top geographies include Other, New York, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06033274 about?
NCT06033274 is a clinical study titled "Global Multicenter Registry on Transcatheter TRIcuspid Valve RePLACEment". The field of transcatheter tricuspid valve replacement (TTVR) is rapidly emerging and data on this topic are scarce. Particularly, little is known about which patients are at greatest risk of procedural complications, such as the timing and onset of conduction disturbances necessitating permanent pa...
What is the current status of trial NCT06033274?
This trial is currently recruiting. The enrollment target is 800 participants. The study started on 2023-10-05. Estimated completion is 2026-08.
What conditions does trial NCT06033274 study?
This clinical trial studies the following conditions: Tricuspid Regurgitation. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06033274?
The interventions under investigation include: Transcatheter Tricuspid Valve Replacement (DEVICE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06033274?
This trial is sponsored by Montefiore Medical Center, which has 280 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06033274 being conducted?
This trial has 20 study locations across Arizona, New York, Ohio, Oregon, British Columbia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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