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NCT06005480 · ClinicalTrials.gov registry record · Phase 1
Understanding Rebound Pain After Regional Anesthesia Resolution in Healthy Volunteers
A Phase 1 study, sponsored by Brigham and Women's Hospital.
- Completed
- Registry status
- Phase 1
- Development phase
- 40
- Enrollment target
NCT06005480: Completed Phase 1 study, sponsored by Brigham and Women's Hospital.
NCT06005480 is a Phase 1 study that has completed, run by Brigham and Women's Hospital. The registered enrollment target is 40 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (33% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06005480, a Phase 1 study, has completed, sponsored by Brigham and Women's Hospital.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 40 participants
- Enrollment target
Study Summary
Regional anesthesia decreases postoperative pain scores and opioid consumption, and may prevent chronic pain after surgery in patients undergoing surgery. However, some patients experience an increase of pain into the severe range when the nerve block wears off, also known as rebound pain. The investigators are studying if a nerve block (numbing injection) in the arm causes hyperalgesia (increased pain) when the nerve block is wearing off.
Primary Outcome
Heat pain detection threshold (°C) between block arm and control arm using a heat probe at 1 hour after nerve block resolution
Interventions
- DRUG Mepivacaine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2023-09-28 |
| Est. Completion | 2024-05-28 |
| Phase | Phase 1 |
What the finished NCT06005480 record still lists
NCT06005480 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (33% lower).
The record links to 0 conditions, and to 1 intervention - of which Mepivacaine is the first listed.
NCT06005480 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06005480 about?
NCT06005480 is a clinical study titled "Understanding Rebound Pain After Regional Anesthesia Resolution in Healthy Volunteers". Regional anesthesia decreases postoperative pain scores and opioid consumption, and may prevent chronic pain after surgery in patients undergoing surgery. However, some patients experience an increase of pain into the severe range when the nerve block wears off, also known as rebound pain. The inves...
What is the current status of trial NCT06005480?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 40 participants. The study started on 2023-09-28. Estimated completion is 2024-05-28.
What interventions are being tested in trial NCT06005480?
The interventions under investigation include: Mepivacaine (DRUG).
Who is sponsoring clinical trial NCT06005480?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06005480's enrollment target sits among peer trials
40 1130th of 2000 higher than 810 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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