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NCT05989581 · ClinicalTrials.gov registry record · Phase 1
Chronic Hypertension and Pregnancy 2 (CHAP2) Pilot Project
A Phase 1 study of Hypertension in Pregnancy, sponsored by University of Alabama at Birmingham.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 74
- Enrollment target
- 1
- Study location
NCT05989581: Recruiting Phase 1 study of Hypertension in Pregnancy, sponsored by University of Alabama at Birmingham.
NCT05989581 is a Phase 1 study of Hypertension in Pregnancy that is actively recruiting participants, run by University of Alabama at Birmingham. The registered enrollment target is 74 participants, below the 443-participant average among 13 other Hypertension in Pregnancy trials with a reported enrollment target (83% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05989581, a Phase 1 study of Hypertension in Pregnancy, is actively recruiting participants, sponsored by University of Alabama at Birmingham.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 74 participants
- Enrollment target
- 1
- Study location
Study Summary
The CHAP2 study is designed to provide preliminary data for a larger multicenter study to assess whether treatment of stage 1 hypertension (HTN) in pregnancy improves maternal and or neonatal outcomes. The primary objective of this pilot study is to determine if anti-HTN treatment to BP\<130/80mmHg in pregnant patients with stage 1 HTN is associated with a difference in birthweight percentile at delivery. Patients with stage 1 hypertension in pregnancy will be randomized to BP goals of \<130/80mmHg or usual care to treatment only if BPs ≥140/90mmHg. For this pilot, the investigator will randomize a total of 74 eligible participants, 37 to active treatment to BP\<130/80mmHg and 37 to usual care.
Primary Outcome
To determine whether anti-HTN treatment to BP\<130/80mmHg in pregnant patients with Stage 1 HTN is associated with a difference in birthweight percentile at delivery
Conditions Studied
Interventions
- DRUG Labetalol or Nifedipine
Study Locations (1)
Alabama
- UAB - Birmingham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 74 participants |
| Start Date | 2024-04-24 |
| Est. Completion | 2026-06-30 |
| Phase | Phase 1 |
What NCT05989581 shows while recruiting
NCT05989581 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 74 participants, a relatively small participant target, below the 443-participant average among 13 other Hypertension in Pregnancy trials with a reported enrollment target (83% lower).
The record links to 1 condition, with Hypertension in Pregnancy appearing as the primary indexed condition, and to 1 intervention - of which Labetalol or Nifedipine is the first listed.
NCT05989581 reports a single indexed study location in Alabama.
Frequently Asked Questions
What is clinical trial NCT05989581 about?
NCT05989581 is a clinical study titled "Chronic Hypertension and Pregnancy 2 (CHAP2) Pilot Project". The CHAP2 study is designed to provide preliminary data for a larger multicenter study to assess whether treatment of stage 1 hypertension (HTN) in pregnancy improves maternal and or neonatal outcomes. The primary objective of this pilot study is to determine if anti-HTN treatment to BP\<130/80mmHg ...
What is the current status of trial NCT05989581?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 74 participants. The study started on 2024-04-24. Estimated completion is 2026-06-30.
What conditions does trial NCT05989581 study?
This clinical trial studies the following conditions: Hypertension in Pregnancy.
What interventions are being tested in trial NCT05989581?
The interventions under investigation include: Labetalol or Nifedipine (DRUG).
Who is sponsoring clinical trial NCT05989581?
This trial is sponsored by University of Alabama at Birmingham, which has 1,160 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05989581 being conducted?
This trial has 1 study location across Alabama. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Hypertension in Pregnancy
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05989581's enrollment target sits among peer trials
74 13th of 13 higher than 1 of 13 other Hypertension in Pregnancy trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Hypertension in Pregnancy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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