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NCT05945628 · ClinicalTrials.gov registry record · NA
Basic Experimental Study of Hippocampal Memory Functions
A NA study, sponsored by University of Chicago.
- Active
- Registry status
- NA
- Development phase
- 66
- Enrollment target
NCT05945628: Active NA study, sponsored by University of Chicago.
NCT05945628 is a NA study that is active but no longer recruiting, run by University of Chicago. The registered enrollment target is 66 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05945628, a NA study, is active but no longer recruiting, sponsored by University of Chicago.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 66 participants
- Enrollment target
Study Summary
This project tests the role of the human hippocampus in providing online representation of episodic content and providing the top-down signals to brain networks for visuospatial attention and visual processing needed to drive visual sampling for the formation of coherent episodic memories. This hypothesis will be tested in several experiments that measure and manipulate hippocampal activity within eye-tracking tasks designed to isolate the interplay between memory and visual sampling during memory formation. These experiments will be performed in individuals with epilepsy undergoing neurosurgical procedures as part of clinical care, as this provides invasive recordings of neural activity (intracranial electroencephalography, or "iEEG") from the hippocampus and other regions of interest with temporal resolution that matches the rapid pace of eye movements. The temporal resolution of iEEG is key to addressing the hypotheses concerning how the hippocampus drives visual sampling, in addition to responding to it. Direct electrical stimulation through the iEEG electrodes will also be used to test the necessary role of hippocampal processing in driving active visual sampling. By rigorously testing the role of hippocampus in interaction with large-scale networks during the process of memory formation that occurs via active sampling, this project aims to better understand mechanisms relevant to the disruptions of memory formation that occur in neurological and psychiatric disorders.
Primary Outcome
iEEG is used to measure slow and fast theta power
Interventions
- BEHAVIORAL Different cognitive and memory demands during the memory experiment
- OTHER Different electrical stimulation parameters during cognitive and memory demands
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 66 participants |
| Start Date | 2023-01-16 |
| Est. Completion | 2027-06 |
| Phase | NA |
What the registry record for NCT05945628 still lists
NCT05945628 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 66 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower).
The record links to 0 conditions, and to 2 interventions - of which Different cognitive and memory demands during the memory experiment is the first listed.
NCT05945628 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05945628 about?
NCT05945628 is a clinical study titled "Basic Experimental Study of Hippocampal Memory Functions". This project tests the role of the human hippocampus in providing online representation of episodic content and providing the top-down signals to brain networks for visuospatial attention and visual processing needed to drive visual sampling for the formation of coherent episodic memories. This hypo...
What is the current status of trial NCT05945628?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 66 participants. The study started on 2023-01-16. Estimated completion is 2027-06.
What interventions are being tested in trial NCT05945628?
The interventions under investigation include: Different cognitive and memory demands during the memory experiment (BEHAVIORAL), Different electrical stimulation parameters during cognitive and memory demands (OTHER).
Who is sponsoring clinical trial NCT05945628?
This trial is sponsored by University of Chicago, which has 796 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05945628's enrollment target sits among peer trials
66 1139th of 2000 higher than 857 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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