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NCT05911841 · ClinicalTrials.gov registry record · Phase 2
A Study of LY3454738 in the Treatment of Adult Participants With Moderate-to-Severe Atopic Dermatitis
A Phase 2 study, sponsored by Eli Lilly and Company.
- Terminated
- Registry status
- Phase 2
- Development phase
- 234
- Enrollment target
NCT05911841: Clinical Trial Phase 2 study, sponsored by Eli Lilly and Company.
NCT05911841 is a Phase 2 study that was terminated before completion, run by Eli Lilly and Company. The registered enrollment target is 234 participants, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (76% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05911841, a Phase 2 study, was terminated before completion, sponsored by Eli Lilly and Company.
- TERMINATED
- Registry status
- Phase 2
- Development phase
- 234 participants
- Enrollment target
Study Summary
The main purpose of this study is to describe the efficacy and safety of LY3454738 in adult participants with moderate-to-severe atopic dermatitis (AD).
Primary Outcome
The EASI assesses objective physician estimates of 2 dimensions of atopic dermatitis - disease extent, i.e., percentage of skin affected: 0 = 0%; 1 = 1-9%; 2 = 10-29%; 3 = 30-49%; 4 = 50-69%; 5 = 70-89%; 6 = 90-100% and the severity of 4 clinical signs: (1) erythema, (2) edema/papulation, (3) excoriation, and (4) lichenification each on a scale of 0 to 3 (0 = none, absent; 1 = mild; 2 = moderate; 3 = severe) at 4 body sites (head/neck, trunk, upper limbs, and lower limbs). Half scores are allowe
Interventions
- DRUG Placebo
- DRUG LY3454738
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 234 participants |
| Start Date | 2023-06-21 |
| Est. Completion | 2025-03-14 |
| Phase | Phase 2 |
Why NCT05911841 stopped before completion
NCT05911841 is an interventional study that assigns participants to a tested intervention. The registered 234 participants enrollment target is mid-sized for trials with a published cap, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (76% higher).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT05911841 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05911841 about?
NCT05911841 is a clinical study titled "A Study of LY3454738 in the Treatment of Adult Participants With Moderate-to-Severe Atopic Dermatitis". The main purpose of this study is to describe the efficacy and safety of LY3454738 in adult participants with moderate-to-severe atopic dermatitis (AD).
What is the current status of trial NCT05911841?
This trial is currently terminated. It is a Phase 2 study. The enrollment target is 234 participants. The study started on 2023-06-21. Estimated completion is 2025-03-14.
What interventions are being tested in trial NCT05911841?
The interventions under investigation include: Placebo (DRUG), LY3454738 (DRUG).
Who is sponsoring clinical trial NCT05911841?
This trial is sponsored by Eli Lilly and Company, which has 1,341 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05911841's enrollment target sits among peer trials
234 255th of 2000 higher than 1,745 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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