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NCT05906602 · ClinicalTrials.gov registry record · NA
Motor and Neurophysiological Changes After Ischemic Conditioning in Individuals With Stroke
A NA study, sponsored by University of Illinois at Chicago.
- Completed
- Registry status
- NA
- Development phase
- 20
- Enrollment target
NCT05906602: Completed NA study, sponsored by University of Illinois at Chicago.
NCT05906602 is a NA study that has completed, run by University of Illinois at Chicago. The registered enrollment target is 20 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05906602, a NA study, has completed, sponsored by University of Illinois at Chicago.
- COMPLETED
- Registry status
- NA
- Development phase
- 20 participants
- Enrollment target
Study Summary
The goal of this clinical trial is to test ischemic conditioning (blood flow restriction) as a neuromodulatory technique to improve gait function in stroke. Neuromodulation is emerging as a promising adjunct strategy to facilitate changes in brain activity and improve motor behavior following a neurological injury such as stroke. The main questions this trial aims to answer are: * Can ischemic conditioning produce neuromodulatory changes in the lower limb primary motor cortex? * Can ischemic conditioning be used as a neuromodulatory technique to improve strength and motor control in individuals with stroke when compared to sham ischemic conditioning? Participants will take part in two sessions of ischemic conditioning where a cuff (similar to ones that measure blood pressure) will be placed around the thigh and inflated to one of two blood flow restriction pressures (real ischemic conditioning (real IC) and sham ischemic conditioning (sham IC)). Each participant will experience measures of brain activity and motor behavior testing before and after both sessions (real IC and sham IC). Researchers will investigate ischemic conditioning as neuromodulation modality in stroke to see if ischemic conditioning can produce beneficial changes in brain activity and improvements on subsequent motor behavior tasks.
Primary Outcome
Excitability of the primary lower limb motor cortex will be assessed using single pulse transcranial magnetic stimulation (TMS) and motor evoked potentials (MEPs) will be recorded from the tibialis anterior muscle of the paretic leg. Higher values indicate more corticomotor excitability.
Interventions
- DEVICE Real Ischemic Conditioning
- DEVICE Sham Ischemic Conditioning
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2024-05-20 |
| Est. Completion | 2025-12-31 |
| Phase | NA |
What the finished NCT05906602 record still lists
NCT05906602 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 2 interventions - of which Real Ischemic Conditioning is the first listed.
NCT05906602 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05906602 about?
NCT05906602 is a clinical study titled "Motor and Neurophysiological Changes After Ischemic Conditioning in Individuals With Stroke". The goal of this clinical trial is to test ischemic conditioning (blood flow restriction) as a neuromodulatory technique to improve gait function in stroke. Neuromodulation is emerging as a promising adjunct strategy to facilitate changes in brain activity and improve motor behavior following a neur...
What is the current status of trial NCT05906602?
This trial is currently completed. It is a NA study. The enrollment target is 20 participants. The study started on 2024-05-20. Estimated completion is 2025-12-31.
What interventions are being tested in trial NCT05906602?
The interventions under investigation include: Real Ischemic Conditioning (DEVICE), Sham Ischemic Conditioning (DEVICE).
Who is sponsoring clinical trial NCT05906602?
This trial is sponsored by University of Illinois at Chicago, which has 430 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05906602's enrollment target sits among peer trials
20 1768th of 2000 higher than 140 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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