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NCT05903794 · ClinicalTrials.gov registry record · Phase 1
A Study of EXG102-031 in Patients With wAMD (Everest)
A Phase 1 study of Neovascular (Wet) Age-related Macular Degeneration (nAMD), sponsored by Exegenesis Bio.
- Active
- Registry status
- Phase 1
- Development phase
- 12
- Enrollment target
- 2
- Study locations
NCT05903794: Active Phase 1 study of Neovascular (Wet) Age-related Macular Degeneration (nAMD), sponsored by Exegenesis Bio.
NCT05903794 is a Phase 1 study of Neovascular (Wet) Age-related Macular Degeneration (nAMD) that is active but no longer recruiting, run by Exegenesis Bio. The registered enrollment target is 12 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (80% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05903794, a Phase 1 study of Neovascular (Wet) Age-related Macular Degeneration (nAMD), is active but no longer recruiting, sponsored by Exegenesis Bio.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 12 participants
- Enrollment target
- 2
- Study locations
Study Summary
In neovascular (wet) age-related macular degeneration (nAMD), the macula, or the part of the eye that provides the clear, detailed central vision, is being affected by abnormal blood vessel growth and leakage. This leakage affects the vision over time and can lead to severe blurriness or blinding. EXG102-031 was made to block the extra vessel formation which would lead to less leakage affecting the vision. Before EXG102-031 can be tested for its efficacy (if it makes vision better), it must be tested to see if it is safely tolerated to confirm it can continue to be studied in more patients with nAMD.
Primary Outcome
Frequency, type, and intensity of ocular and non-ocular adverse events (AEs) and serious adverse events (SAEs)
Conditions Studied
Interventions
- BIOLOGICAL EXG102-031
Study Locations (2)
Nevada
- Sierra Eye Associates - Reno
Pennsylvania
- Erie Retina Research - Erie
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 12 participants |
| Start Date | 2023-07-24 |
| Est. Completion | 2026-02-28 |
| Phase | Phase 1 |
What the registry record for NCT05903794 still lists
NCT05903794 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 12 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (80% lower).
The record links to 1 condition, with Neovascular (Wet) Age-related Macular Degeneration (nAMD) appearing as the primary indexed condition, and to 1 intervention - of which EXG102-031 is the first listed.
NCT05903794 reports a single indexed study location in Nevada, Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT05903794 about?
NCT05903794 is a clinical study titled "A Study of EXG102-031 in Patients With wAMD (Everest)". In neovascular (wet) age-related macular degeneration (nAMD), the macula, or the part of the eye that provides the clear, detailed central vision, is being affected by abnormal blood vessel growth and leakage. This leakage affects the vision over time and can lead to severe blurriness or blinding. E...
What is the current status of trial NCT05903794?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 12 participants. The study started on 2023-07-24. Estimated completion is 2026-02-28.
What conditions does trial NCT05903794 study?
This clinical trial studies the following conditions: Neovascular (Wet) Age-related Macular Degeneration (nAMD).
What interventions are being tested in trial NCT05903794?
The interventions under investigation include: EXG102-031 (BIOLOGICAL).
Who is sponsoring clinical trial NCT05903794?
This trial is sponsored by Exegenesis Bio, which has 2 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05903794 being conducted?
This trial has 2 study locations across Nevada, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05903794's enrollment target sits among peer trials
12 1852nd of 2000 higher than 90 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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