Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 1

Intra-Tumoral Injections of Natural Killer Cells for Recurrent Malignant Pediatric Brain Tumors

NCT05887882 · View on ClinicalTrials.gov ↗

Study Summary

This phase I trial tests the safety, side effects, and best dose of ex vivo expanded natural killer cells in treating patients with cancerous (malignant) tumors affecting the upper part of the brain (supratentorial) that have come back (recurrent) or that are growing, spreading, or getting worse (progressive). Natural killer (NK) cells are immune cells that recognize and get rid of abnormal cells in the body, including tumor cells and cells infected by viruses. NK cells have been shown to kill different types of cancer, including brain tumors in laboratory settings. Giving NK cells from unrelated donors who are screened for optimal cell qualities and determined to be safe and healthy may be effective in treating supratentorial malignant brain tumors in children and young adults.

Interventions

  • OTHER Quality-of-Life Assessment
  • PROCEDURE Magnetic Resonance Imaging (MRI)
  • BIOLOGICAL Universal Donor (UD) Transforming growth factor beta imprinting (TGFβi) Natural Killer (NK) Cells
  • PROCEDURE Implantation

Study Locations (8)

Alabama

  • University of Alabama Birmingham — Birmingham

California

  • University of California, San Francisco — San Francisco

Indiana

  • Indiana University — Indianapolis

Maryland

  • Johns Hopkins — Baltimore

Missouri

  • Washington University in Saint Louis — St Louis

New Jersey

  • Hackensack University Medical Center — Hackensack

Ohio

  • Nationwide Children's Hospital — Columbus

Washington

  • Seattle Children's — Seattle

Trial Details

FieldValue
Enrollment Target 24 participants
Start Date 2024-05-31
Est. Completion 2027-12-31
Phase Phase 1

Sponsor

Sabine Mueller, MD, PhD

6 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05887882

The ClinicalTrials.gov registry entry for NCT05887882 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 24 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Sabine Mueller, MD, PhD, which has 6 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 3 conditions, with Pediatric Brain Tumor appearing as the primary indexed condition, and to 4 interventions — of which Quality-of-Life Assessment is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05887882 reports 8 study locations spanning 8 distinct geographic areas — top geographies include Alabama, California, Indiana. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05887882 about?

NCT05887882 is a clinical study titled "Intra-Tumoral Injections of Natural Killer Cells for Recurrent Malignant Pediatric Brain Tumors". This phase I trial tests the safety, side effects, and best dose of ex vivo expanded natural killer cells in treating patients with cancerous (malignant) tumors affecting the upper part of the brain (supratentorial) that have come back (recurrent) or that are growing, spreading, or getting worse (pr...

What is the current status of trial NCT05887882?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 24 participants. The study started on 2024-05-31. Estimated completion is 2027-12-31.

What conditions does trial NCT05887882 study?

This clinical trial studies the following conditions: Pediatric Brain Tumor, Pediatric Neoplasm, Recurrent Pediatric Brain Tumor. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05887882?

The interventions under investigation include: Quality-of-Life Assessment (OTHER), Magnetic Resonance Imaging (MRI) (PROCEDURE), Universal Donor (UD) Transforming growth factor beta imprinting (TGFβi) Natural Killer (NK) Cells (BIOLOGICAL), Implantation (PROCEDURE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05887882?

This trial is sponsored by Sabine Mueller, MD, PhD, which has 6 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05887882 being conducted?

This trial has 8 study locations across Alabama, California, Indiana, Maryland, Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial