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NCT05820932 · ClinicalTrials.gov registry record
Predicting Cognitive Decline From Androgen Deprivation Therapy
A clinical trial of Prostate Cancer, sponsored by University of California, San Francisco.
- Active
- Registry status
- 32
- Enrollment target
- 1
- Study location
NCT05820932 is a study of Prostate Cancer that is active but no longer recruiting, run by University of California, San Francisco. The registered enrollment target is 32 participants, below the 608-participant average among 735 other Prostate Cancer trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state.
The verdict
NCT05820932, a study of Prostate Cancer, is active but no longer recruiting, sponsored by University of California, San Francisco.
- ACTIVE NOT RECRUITING
- Registry status
- 32 participants
- Enrollment target
- 1
- Study location
Study Summary
Androgen Deprivation Therapy (ADT) is associated with cognitive impairment and dementia in men with prostate cancer. Pre-clinical data suggest that ADT-induced hypogonadism leads to accumulation of beta-amyloid plaques in the hippocampus, a pathological hallmark of Alzheimer's Disease (AD). Neuroimaging Functional magnetic resonance imaging (fMRI) studies also demonstrate that ADT decreases metabolic activity in the parietal, occipital, and prefrontal cortices. Multiple prospective cohort and population-based clinical studies have been conducted to test the association between ADT and cognitive impairment and/or dementia. Plasma biomarkers have been developed to predict brain amyloidosis, a key pathological feature of AD and a risk factor for developing dementia due to AD. The advantage of a blood-based assay is the lower cost, invasiveness, and time compared to cerebrospinal fluid (CSF) and Positron Emission Tomography (PET)-based biomarkers.
Conditions Studied
Interventions
- GENETIC Blood-based assay
- DIAGNOSTIC_TEST Cognitive assessments
- OTHER Quality of Life Surveys
Study Locations (1)
California
- University of California, San Francisco - San Francisco
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 32 participants |
| Start Date | 2023-05-22 |
| Est. Completion | 2026-02-28 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05820932
The ClinicalTrials.gov registry entry for NCT05820932 describes a study currently listed as active not recruiting, categorized as an unspecified phase. The registered enrollment target is 32 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 608-participant average among 735 other Prostate Cancer trials with a reported enrollment target (95% lower). The listed sponsor is University of California, San Francisco, which has 1,713 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Prostate Cancer appearing as the primary indexed condition, and to 3 interventions - of which Blood-based assay is the first listed.
NCT05820932 reports 1 study location spanning 1 distinct geographic area - top geographies include California.
Frequently Asked Questions
What is clinical trial NCT05820932 about?
NCT05820932 is a clinical study titled "Predicting Cognitive Decline From Androgen Deprivation Therapy". Androgen Deprivation Therapy (ADT) is associated with cognitive impairment and dementia in men with prostate cancer. Pre-clinical data suggest that ADT-induced hypogonadism leads to accumulation of beta-amyloid plaques in the hippocampus, a pathological hallmark of Alzheimer's Disease (AD). Neuroima...
What is the current status of trial NCT05820932?
This trial is currently active not recruiting. The enrollment target is 32 participants. The study started on 2023-05-22. Estimated completion is 2026-02-28.
What conditions does trial NCT05820932 study?
This clinical trial studies the following conditions: Prostate Cancer.
What interventions are being tested in trial NCT05820932?
The interventions under investigation include: Blood-based assay (GENETIC), Cognitive assessments (DIAGNOSTIC_TEST), Quality of Life Surveys (OTHER).
Who is sponsoring clinical trial NCT05820932?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05820932 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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