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NCT05816785 · ClinicalTrials.gov registry record · Early Phase 1
Pilot Study of Imatinib Cetuximab Combo for H & N Cancer
A Early Phase 1 study of Head and Neck Cancer and Squamous Cell Carcinoma of Head and Neck, sponsored by University of Wisconsin, Madison.
- Active
- Registry status
- Early Phase 1
- Development phase
- 15
- Enrollment target
- 1
- Study location
NCT05816785: Active Early Phase 1 study of Head and Neck Cancer and Squamous Cell Carcinoma of Head and Neck, sponsored by University of Wisconsin, Madison.
NCT05816785 is a Early Phase 1 study of Head and Neck Cancer and Squamous Cell Carcinoma of Head and Neck that is active but no longer recruiting, run by University of Wisconsin, Madison. The registered enrollment target is 15 participants, below the 261-participant average among 250 other Head and Neck Cancer trials with a reported enrollment target (94% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05816785, a Early Phase 1 study of Head and Neck Cancer and Squamous Cell Carcinoma of Head and Neck, is active but no longer recruiting, sponsored by University of Wisconsin, Madison.
- ACTIVE NOT RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 15 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to find if levels of a protein called AXL in tumor cells relate to how tumors respond to cetuximab (CTX) combined with imatinib in participants with head and neck cancer. This interventional study will occur in the time between diagnosis of your cancer and surgery to remove your tumor or radiation or chemoradiation treatment of your primary cancer. Participants will undergo a research blood draw and a research biopsy as part of the screening process, and will be in this research study for approximately 13 to 16 months.
Primary Outcome
The change in Ki67 is calculated as the ratio of pre- to post- treatment Ki67 index
Conditions Studied
Interventions
- DRUG Cetuximab
- DRUG Imatinib
Study Locations (1)
Wisconsin
- University of Wisconsin Carbone Cancer Center - Madison
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2023-04-18 |
| Est. Completion | 2026-04-30 |
| Phase | Early Phase 1 |
What the registry record for NCT05816785 still lists
NCT05816785 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 15 participants, a relatively small participant target, below the 261-participant average among 250 other Head and Neck Cancer trials with a reported enrollment target (94% lower).
The record links to 2 conditions, with Head and Neck Cancer appearing as the primary indexed condition, and to 2 interventions - of which Cetuximab is the first listed.
NCT05816785 reports a single indexed study location in Wisconsin.
Frequently Asked Questions
What is clinical trial NCT05816785 about?
NCT05816785 is a clinical study titled "Pilot Study of Imatinib Cetuximab Combo for H & N Cancer". The goal of this clinical trial is to find if levels of a protein called AXL in tumor cells relate to how tumors respond to cetuximab (CTX) combined with imatinib in participants with head and neck cancer. This interventional study will occur in the time between diagnosis of your cancer and surgery ...
What is the current status of trial NCT05816785?
This trial is currently active not recruiting. It is a Early Phase 1 study. The enrollment target is 15 participants. The study started on 2023-04-18. Estimated completion is 2026-04-30.
What conditions does trial NCT05816785 study?
This clinical trial studies the following conditions: Head and Neck Cancer, Squamous Cell Carcinoma of Head and Neck.
What interventions are being tested in trial NCT05816785?
The interventions under investigation include: Cetuximab (DRUG), Imatinib (DRUG).
Who is sponsoring clinical trial NCT05816785?
This trial is sponsored by University of Wisconsin, Madison, which has 1,039 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05816785 being conducted?
This trial has 1 study location across Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Head and Neck Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05816785's enrollment target sits among peer trials
15 227th of 250 higher than 22 of 250 other Head and Neck Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Head and Neck Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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