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NCT05773001 · ClinicalTrials.gov registry record · Phase 1
Macrophage Regulation of Ozone-Induced Lung Inflammation
A Phase 1 study of SARS-CoV-2 Pneumonia, sponsored by Robert Tighe, MD.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 100
- Enrollment target
- 1
- Study location
NCT05773001: Recruiting Phase 1 study of SARS-CoV-2 Pneumonia, sponsored by Robert Tighe, MD.
NCT05773001 is a Phase 1 study of SARS-CoV-2 Pneumonia that is actively recruiting participants, run by Robert Tighe, MD. The registered enrollment target is 100 participants, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (67% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05773001, a Phase 1 study of SARS-CoV-2 Pneumonia, is actively recruiting participants, sponsored by Robert Tighe, MD.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 100 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this research study to understand how prior respiratory infections affect the susceptibility to lung inflammation following environmental exposures.
Primary Outcome
Change in the abundance of monocyte-derived alveolar macrophages and association to measures of O3-induced inflammation (BAL cell neutrophils, albumin and cytokine production)
Conditions Studied
Interventions
- DRUG Ozone
Study Locations (1)
North Carolina
- Duke University Medical Center - Durham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2023-05-18 |
| Est. Completion | 2028-05 |
| Phase | Phase 1 |
What NCT05773001 shows while recruiting
NCT05773001 is an interventional study that assigns participants to a tested intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (67% higher).
The record links to 1 condition, with SARS-CoV-2 Pneumonia appearing as the primary indexed condition, and to 1 intervention - of which Ozone is the first listed.
NCT05773001 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT05773001 about?
NCT05773001 is a clinical study titled "Macrophage Regulation of Ozone-Induced Lung Inflammation". The purpose of this research study to understand how prior respiratory infections affect the susceptibility to lung inflammation following environmental exposures.
What is the current status of trial NCT05773001?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 100 participants. The study started on 2023-05-18. Estimated completion is 2028-05.
What conditions does trial NCT05773001 study?
This clinical trial studies the following conditions: SARS-CoV-2 Pneumonia.
What interventions are being tested in trial NCT05773001?
The interventions under investigation include: Ozone (DRUG).
Who is sponsoring clinical trial NCT05773001?
This trial is sponsored by Robert Tighe, MD, which has 3 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05773001 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05773001's enrollment target sits among peer trials
100 547th of 2000 higher than 1,411 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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