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NCT05715216 · ClinicalTrials.gov registry record · Phase 2
EON: A Single-arm Phase II Study of Etigilimab (OMP-313M32) in Combination With Checkpoint Inhibition (Nivolumab) in Patients With Platinum-resistant, Recurrent Epithelial Ovarian Cancer
A Phase 2 study of Ovarian Cancer, sponsored by M.D. Anderson Cancer Center.
- Active
- Registry status
- Phase 2
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT05715216: Active Phase 2 study of Ovarian Cancer, sponsored by M.D. Anderson Cancer Center.
NCT05715216 is a Phase 2 study of Ovarian Cancer that is active but no longer recruiting, run by M.D. Anderson Cancer Center. The registered enrollment target is 20 participants, below the 729-participant average among 322 other Ovarian Cancer trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05715216, a Phase 2 study of Ovarian Cancer, is active but no longer recruiting, sponsored by M.D. Anderson Cancer Center.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
To learn if adding etigilimab to nivolumab therapy can help to control clear cell ovarian, fallopian tube, and primary peritoneal cancers that are resistant to platinum-based therapy
Primary Outcome
Clinical benefit was defined as objective response or stable disease (SD) for greater than or equal to 4 months. Best overall response will be used for estimating Objective Response Rate, Complete Response (CR) + Partial Response (PR).
Conditions Studied
Interventions
- DRUG Nivolumab
- DRUG Etigilimab
Study Locations (1)
Texas
- M D Anderson Cancer Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2023-03-24 |
| Est. Completion | 2026-02-08 |
| Phase | Phase 2 |
What the registry record for NCT05715216 still lists
NCT05715216 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 729-participant average among 322 other Ovarian Cancer trials with a reported enrollment target (97% lower).
The record links to 1 condition, with Ovarian Cancer appearing as the primary indexed condition, and to 2 interventions - of which Nivolumab is the first listed.
NCT05715216 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT05715216 about?
NCT05715216 is a clinical study titled "EON: A Single-arm Phase II Study of Etigilimab (OMP-313M32) in Combination With Checkpoint Inhibition (Nivolumab) in Patients With Platinum-resistant, Recurrent Epithelial Ovarian Cancer". To learn if adding etigilimab to nivolumab therapy can help to control clear cell ovarian, fallopian tube, and primary peritoneal cancers that are resistant to platinum-based therapy
What is the current status of trial NCT05715216?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 20 participants. The study started on 2023-03-24. Estimated completion is 2026-02-08.
What conditions does trial NCT05715216 study?
This clinical trial studies the following conditions: Ovarian Cancer.
What interventions are being tested in trial NCT05715216?
The interventions under investigation include: Nivolumab (DRUG), Etigilimab (DRUG).
Who is sponsoring clinical trial NCT05715216?
This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05715216 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Ovarian Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05715216's enrollment target sits among peer trials
20 284th of 322 higher than 34 of 322 other Ovarian Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Ovarian Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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