Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05707663 · ClinicalTrials.gov registry record
Longitudinal Assessment of Brain Structure and Function in Juvenile-onset Huntington's Disease
A clinical trial of Juvenile Huntington Disease and Juvenile-Onset Huntington Disease, sponsored by University of Iowa.
- Recruiting
- Registry status
- 40
- Enrollment target
- 6
- Study locations
NCT05707663: Recruiting study of Juvenile Huntington Disease and Juvenile-Onset Huntington Disease, sponsored by University of Iowa.
NCT05707663 is a study of Juvenile Huntington Disease and Juvenile-Onset Huntington Disease that is actively recruiting participants, run by University of Iowa. The registered enrollment target is 40 participants. The trial reports 6 study locations across 6 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05707663, a study of Juvenile Huntington Disease and Juvenile-Onset Huntington Disease, is actively recruiting participants, sponsored by University of Iowa.
- RECRUITING
- Registry status
- 40 participants
- Enrollment target
- 6
- Study locations
Study Summary
The goal of this observational study is to learn about brain development in Juvenile-onset Huntington's Disease (JoHD). The main questions it aims to answer are: * Is brain development different in JoHD than Adult-onset Huntington's Disease (AoHD)? * Can reliable biomarkers for JoHD be found in brain structure and function? Participants will be asked to complete cognitive tests, behavioral assessments, physical and neurologic evaluation, and MRI. Data collected will be compared to populations who are at-risk for HD and who have been diagnosed with HD as adults.
Primary Outcome
Magnetic Resonance Imaging (MRI) and Diffusion Tensor Imaging (DTI) data will be analyzed to assess brain structure based upon variables including global volume, total cerebral spinal fluid, subregion volumes, cortical surface anatomy including cortical depth, surface area and gyral shape, and symmetry between brain hemispheres.
Conditions Studied
Study Locations (6)
California
- University of California Davis - Sacramento
Iowa
- University of Iowa Hospitals and Clinics, Department of Psychiatry - Iowa City
New York
- Columbia University Medical Center - New York
Pennsylvania
- Children's Hospital of Philadelphia with the University of Pennsylvania - Philadelphia
Tennessee
- Vanderbilt University Medical Center - Nashville
Texas
- University of Texas Health Science Center at Houston - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2020-01-01 |
| Est. Completion | 2026-08-31 |
What NCT05707663 shows while recruiting
NCT05707663 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 40 participants, a relatively small participant target.
The record links to 2 conditions, with Juvenile Huntington Disease appearing as the primary indexed condition, and to 0 interventions.
NCT05707663 lists 6 locations in 6 states (California, Iowa, New York).
Frequently Asked Questions
What is clinical trial NCT05707663 about?
NCT05707663 is a clinical study titled "Longitudinal Assessment of Brain Structure and Function in Juvenile-onset Huntington's Disease". The goal of this observational study is to learn about brain development in Juvenile-onset Huntington's Disease (JoHD). The main questions it aims to answer are: * Is brain development different in JoHD than Adult-onset Huntington's Disease (AoHD)? * Can reliable biomarkers for JoHD be found in bra...
What is the current status of trial NCT05707663?
This trial is currently recruiting. The enrollment target is 40 participants. The study started on 2020-01-01. Estimated completion is 2026-08-31.
What conditions does trial NCT05707663 study?
This clinical trial studies the following conditions: Juvenile Huntington Disease, Juvenile-Onset Huntington Disease.
Who is sponsoring clinical trial NCT05707663?
This trial is sponsored by University of Iowa, which has 228 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05707663 being conducted?
This trial has 6 study locations across California, Iowa, New York, Pennsylvania, Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01306019 · 40 participants · Phase 1
Lentiviral Gene Transfer for Treatment of Children Older Than Two Years of Age With X-Linked Severe Combined Immunodeficiency (XSCID)
- NCT01608152 · 40 participants
Development of a Video Game for the Improvement of Outcomes in Stem Cell Transplant Survivors
- NCT01668082 · 40 participants · NA
An Investigation of Brain Tumor Metabolism in Patients Undergoing Surgical Resection
- NCT02015013 · 40 participants · Phase 2
Hematopoietic Stem Cell Mobilization in Idiopathic CD4 Lymphocytopenia Patients and Healthy Controls for the Study of T Cell Maturation and Trafficking in Murine Models
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI