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Quaratusugene Ozeplasmid (Reqorsa) and Atezolizumab Maintenance Therapy in ES-SCLC Patients
NCT05703971 · View on ClinicalTrials.gov ↗
Study Summary
This clinical trial will evaluate the combination of quaratusugene ozeplasmid with atezolizumab as maintenance therapy for patients with Extensive Stage Small Cell Lung Cancer (ES-SCLC). The study is comprised of 2 phases, a dose selection phase (Phase 1) and a safety and efficacy evaluation phase (Phase 2).
Conditions Studied
Interventions
- BIOLOGICAL quaratusugene ozeplasmid
- BIOLOGICAL atezolizumab
Study Locations (17)
Ohio
- Gabrail Cancer Center Research — Canton
- Oncology_Hematology Care Clinical Trials, LLC — Cincinnati
- Oncology_Hematology Care Clinical Trials, LLC — Cincinnati
- Oncology_Hematology Care Clinical Trials, LLC — Cincinnati
- Oncology_Hematology Care Clinical Trials, LLC — Cincinnati
- Oncology_Hematology Care Clinical Trials, LLC — Fairfield
Oregon
- Willamette Valley Cancer Institute (Oregon) — Eugene
- Northwest Cancer Specialists, P.C. — Portland
- Providence Cancer Institute — Portland
- Northwest Cancer Specialists, P.C. — Portland
- Northwest Cancer Specialists, P.C. — Tigard
Texas
- Texas Oncology - DFW — Dallas
- Texas Oncology - Northeast Texas — Tyler
Colorado
- Rocky Mountain Cancer Centers, LLP — Lone Tree
Missouri
- Washington University School of Medicine - Siteman Cancer Center — St Louis
Virginia
- Virginia Cancer Specialists, PC — Fairfax
Washington
- Northwest Cancer Specialists, P.C. — Vancouver
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 62 participants |
| Start Date | 2024-05-09 |
| Est. Completion | 2027-08 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05703971
The ClinicalTrials.gov registry entry for NCT05703971 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 62 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Genprex, which has 33 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Small Cell Lung Cancer Extensive Stage appearing as the primary indexed condition, and to 2 interventions — of which quaratusugene ozeplasmid is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05703971 reports 17 study locations spanning 7 distinct geographic areas — top geographies include Ohio, Oregon, Texas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05703971 about?
NCT05703971 is a clinical study titled "Quaratusugene Ozeplasmid (Reqorsa) and Atezolizumab Maintenance Therapy in ES-SCLC Patients". This clinical trial will evaluate the combination of quaratusugene ozeplasmid with atezolizumab as maintenance therapy for patients with Extensive Stage Small Cell Lung Cancer (ES-SCLC). The study is comprised of 2 phases, a dose selection phase (Phase 1) and a safety and efficacy evaluation phase ...
What is the current status of trial NCT05703971?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 62 participants. The study started on 2024-05-09. Estimated completion is 2027-08.
What conditions does trial NCT05703971 study?
This clinical trial studies the following conditions: Small Cell Lung Cancer Extensive Stage. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05703971?
The interventions under investigation include: quaratusugene ozeplasmid (BIOLOGICAL), atezolizumab (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05703971?
This trial is sponsored by Genprex, which has 33 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05703971 being conducted?
This trial has 17 study locations across Colorado, Missouri, Ohio, Oregon, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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