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NCT05697172 · ClinicalTrials.gov registry record · NA
Low Intensity Ultrasound Neuromodulation of Repetitive Negative Thinking In Depression
A NA study, sponsored by Laureate Institute for Brain Research.
- Completed
- Registry status
- NA
- Development phase
- 30
- Enrollment target
NCT05697172 is a NA study that has completed, run by Laureate Institute for Brain Research. The registered enrollment target is 30 participants.
The verdict
NCT05697172, a NA study, has completed, sponsored by Laureate Institute for Brain Research.
- COMPLETED
- Registry status
- NA
- Development phase
- 30 participants
- Enrollment target
Study Summary
The investigators propose to use low-intensity transcranial focused ultrasound (LIFU), a novel neuromodulation method, to probe the causal involvement of individually defined components of an anteromedial brain circuit in the processing of self-referential thoughts, and the production of repetitive negative thinking (RNT), a prominent transdiagnostic manifestation with adverse clinical consequences. The investigators hypothesize that real vs. sham low-intensity sonication of individually-defined anteromedial structures connecting medial orbitofrontal and anterior cingulate cortices with ventral striatum and anterior thalamus will show reduced initiation or maintenance of RNT as measured by (1) Brief State Rumination Inventory (BSRI) scores and distress associated to repetitive negative thoughts, and (2) improvement of the affective valence associated to self-referential adjectives, and that these changes will be associated with decreased connectivity between structures mentioned above. The present early feasibility study is an initial step that aims to determine its feasibility and help with the planning of a larger study addressed at actual hypothesis testing.
Interventions
- OTHER Low-intensity focused ultrasound
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2022-12-15 |
| Est. Completion | 2024-02-06 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05697172
The ClinicalTrials.gov registry entry for NCT05697172 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 30 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Laureate Institute for Brain Research, which has 45 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Low-intensity focused ultrasound is the first listed.
NCT05697172 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT05697172 about?
NCT05697172 is a clinical study titled "Low Intensity Ultrasound Neuromodulation of Repetitive Negative Thinking In Depression". The investigators propose to use low-intensity transcranial focused ultrasound (LIFU), a novel neuromodulation method, to probe the causal involvement of individually defined components of an anteromedial brain circuit in the processing of self-referential thoughts, and the production of repetitive ...
What is the current status of trial NCT05697172?
This trial is currently completed. It is a NA study. The enrollment target is 30 participants. The study started on 2022-12-15. Estimated completion is 2024-02-06.
What interventions are being tested in trial NCT05697172?
The interventions under investigation include: Low-intensity focused ultrasound (OTHER).
Who is sponsoring clinical trial NCT05697172?
This trial is sponsored by Laureate Institute for Brain Research, which has 45 total clinical trials registered on ClinicalTrials.gov.
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