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NCT05692180 · ClinicalTrials.gov registry record · Phase 3
A Multicentre, Randomised, Double-blind, Parallel Group, Placebo-controlled, Time-to-first Asthma Exacerbation Phase III Efficacy and Safety Study of Benralizumab in Paediatric Patients With Severe Eosinophilic Asthma (DOMINICA)
A Phase 3 study of Asthma, sponsored by AstraZeneca.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 200
- Enrollment target
- 20
- Study locations
NCT05692180: Recruiting Phase 3 study of Asthma, sponsored by AstraZeneca.
NCT05692180 is a Phase 3 study of Asthma that is actively recruiting participants, run by AstraZeneca. The registered enrollment target is 200 participants, below the 1,563-participant average among 374 other Asthma trials with a reported enrollment target (87% lower). The trial reports 20 study locations across 14 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05692180, a Phase 3 study of Asthma, is actively recruiting participants, sponsored by AstraZeneca.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 200 participants
- Enrollment target
- 20
- Study locations
Study Summary
A study to evaluate the efficacy and safety of benralizumab administered subcutaneously in patients ≥ 6 to \< 18 years of age with severe eosinophilic asthma, including a well-documented history of asthma exacerbations and uncontrolled asthma receiving high-dose inhaled corticosteroid (ICS) plus at least one additional controller medication.
Primary Outcome
The effect of benralizumab on asthma exacerbations in paediatric and adolescent patients with uncontrolled asthma will be evaluated.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Benralizumab
Study Locations (20)
Florida
- Research Site - Miami
- Research Site - Miami
- Research Site - Ocala
Alabama
- Research Site - Mobile
- Research Site - Montgomery
California
- Research Site - Madera
- Research Site - Torrance
Louisiana
- Research Site - Lafayette
- Research Site - New Orleans
New Jersey
- Research Site - Brick
- Research Site - Northfield
Arizona
- Research Site - Tucson
Arkansas
- Research Site - Little Rock
District of Columbia
- Research Site - Washington D.C.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 200 participants |
| Start Date | 2023-04-05 |
| Est. Completion | 2032-05-16 |
| Phase | Phase 3 |
What NCT05692180 shows while recruiting
NCT05692180 is an interventional study that assigns participants to a tested intervention. The registered 200 participants enrollment target is mid-sized for trials with a published cap, below the 1,563-participant average among 374 other Asthma trials with a reported enrollment target (87% lower).
The record links to 1 condition, with Asthma appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT05692180 names 20 study sites across 14 states, led by Florida, Alabama, California.
Frequently Asked Questions
What is clinical trial NCT05692180 about?
NCT05692180 is a clinical study titled "A Multicentre, Randomised, Double-blind, Parallel Group, Placebo-controlled, Time-to-first Asthma Exacerbation Phase III Efficacy and Safety Study of Benralizumab in Paediatric Patients With Severe Eosinophilic Asthma (DOMINICA)". A study to evaluate the efficacy and safety of benralizumab administered subcutaneously in patients ≥ 6 to \< 18 years of age with severe eosinophilic asthma, including a well-documented history of asthma exacerbations and uncontrolled asthma receiving high-dose inhaled corticosteroid (ICS) plus at ...
What is the current status of trial NCT05692180?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 200 participants. The study started on 2023-04-05. Estimated completion is 2032-05-16.
What conditions does trial NCT05692180 study?
This clinical trial studies the following conditions: Asthma.
What interventions are being tested in trial NCT05692180?
The interventions under investigation include: Placebo (DRUG), Benralizumab (DRUG).
Who is sponsoring clinical trial NCT05692180?
This trial is sponsored by AstraZeneca, which has 1,285 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05692180 being conducted?
This trial has 20 study locations across Alabama, Arizona, Arkansas, California, District of Columbia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Asthma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05692180's enrollment target sits among peer trials
200 162nd of 374 higher than 210 of 374 other Asthma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Asthma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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