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NCT05662280 · ClinicalTrials.gov registry record · NA
NIMH K23: Modulation of Frontoparietal Dynamics in Adolescent Working Memory Deficits
A NA study of Working Memory, sponsored by Bradley Hospital.
- Active
- Registry status
- NA
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT05662280: Active NA study of Working Memory, sponsored by Bradley Hospital.
NCT05662280 is a NA study of Working Memory that is active but no longer recruiting, run by Bradley Hospital. The registered enrollment target is 40 participants, below the 60-participant average among 5 other Working Memory trials with a reported enrollment target (33% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05662280, a NA study of Working Memory, is active but no longer recruiting, sponsored by Bradley Hospital.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
Working memory (WM) deficits are a transdiagnostic feature of adolescent psychopathology that substantially contribute to poor clinical and functional outcomes. This proposal will utilize a multimodal neuroscientific approach to investigate whether non-invasive brain stimulation can modulate the neural mechanisms underlying adolescent WM deficits. Directly in line with NIMH priorities, the researchers will identify the contributing roles of prefrontal and parietal regions in WM processes, as well as identify optimal targets and parameters for novel brain-based treatments in adolescent psychopathology. This study is funded by the NIMH-K23
Primary Outcome
EEG recording will be obtained while the participant completes the Sternberg Spatial Working Memory Test (SWMT). The coupling between theta phase and gamma amplitude will be extracted from the EEG during encoding and maintaining demands. The change between pre and post a single iTBS session will be calculated.
Conditions Studied
Interventions
- DEVICE Active Intermittent Theta Burst Stimulation
- DEVICE Sham Intermittent Theta Burst Stimulation
Study Locations (1)
Rhode Island
- E. P. Bradley Hospital - East Providence
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2022-12-01 |
| Est. Completion | 2026-12-01 |
| Phase | NA |
What the registry record for NCT05662280 still lists
NCT05662280 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 60-participant average among 5 other Working Memory trials with a reported enrollment target (33% lower).
The record links to 1 condition, with Working Memory appearing as the primary indexed condition, and to 2 interventions - of which Active Intermittent Theta Burst Stimulation is the first listed.
NCT05662280 reports a single indexed study location in Rhode Island.
Frequently Asked Questions
What is clinical trial NCT05662280 about?
NCT05662280 is a clinical study titled "NIMH K23: Modulation of Frontoparietal Dynamics in Adolescent Working Memory Deficits". Working memory (WM) deficits are a transdiagnostic feature of adolescent psychopathology that substantially contribute to poor clinical and functional outcomes. This proposal will utilize a multimodal neuroscientific approach to investigate whether non-invasive brain stimulation can modulate the neu...
What is the current status of trial NCT05662280?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 40 participants. The study started on 2022-12-01. Estimated completion is 2026-12-01.
What conditions does trial NCT05662280 study?
This clinical trial studies the following conditions: Working Memory.
What interventions are being tested in trial NCT05662280?
The interventions under investigation include: Active Intermittent Theta Burst Stimulation (DEVICE), Sham Intermittent Theta Burst Stimulation (DEVICE).
Who is sponsoring clinical trial NCT05662280?
This trial is sponsored by Bradley Hospital, which has 12 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05662280 being conducted?
This trial has 1 study location across Rhode Island. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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