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NCT05654012 · ClinicalTrials.gov registry record · NA
Migraine in Adolescents
A NA study of Migraine, sponsored by Washington University School of Medicine.
- Recruiting
- Registry status
- NA
- Development phase
- 250
- Enrollment target
- 1
- Study location
NCT05654012: Recruiting NA study of Migraine, sponsored by Washington University School of Medicine.
NCT05654012 is a NA study of Migraine that is actively recruiting participants, run by Washington University School of Medicine. The registered enrollment target is 250 participants, below the 356-participant average among 102 other Migraine trials with a reported enrollment target (30% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05654012, a NA study of Migraine, is actively recruiting participants, sponsored by Washington University School of Medicine.
- RECRUITING
- Registry status
- NA
- Development phase
- 250 participants
- Enrollment target
- 1
- Study location
Study Summary
Aim 1. To identify psychophysical and neural factors predicting migraine onset in adolescents Aim 2a. To determine hormonal, psychophysical, and neural changes associated with migraine onset. Aim 2b. To identify the temporal relationships between hormonal, psychophysical, and neural changes preceding vs. following migraine onset. Aim 3. To identify psychophysical and neural factors predicting migraine prognosis in adolescents with migraine.
Primary Outcome
Multivariable regression analyses with baseline psychophysical, and neural factors will be used to identify predictors for migraine diagnosis and headache frequency. For Aim 1a, the primary outcome is migraine diagnosis (binary variable based on the physician's diagnosis), the independent variables are baseline PPT, CPM response, and FC of the right amygdala, and the controlling factors are race and age.
Conditions Studied
Interventions
- DEVICE MRI
- DEVICE Thermal Stimuli
- DEVICE Pressure stimuli
- BEHAVIORAL Pain ratings
- BEHAVIORAL Pressure pain thresholds (PPT)
Study Locations (1)
Missouri
- Washington University School of Medicine - St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 250 participants |
| Start Date | 2023-06-01 |
| Est. Completion | 2030-03-15 |
| Phase | NA |
What NCT05654012 shows while recruiting
NCT05654012 is an interventional study that assigns participants to a tested intervention. The registered 250 participants enrollment target is mid-sized for trials with a published cap, below the 356-participant average among 102 other Migraine trials with a reported enrollment target (30% lower).
The record links to 1 condition, with Migraine appearing as the primary indexed condition, and to 5 interventions - of which MRI is the first listed.
NCT05654012 reports a single indexed study location in Missouri.
Frequently Asked Questions
What is clinical trial NCT05654012 about?
NCT05654012 is a clinical study titled "Migraine in Adolescents". Aim 1. To identify psychophysical and neural factors predicting migraine onset in adolescents Aim 2a. To determine hormonal, psychophysical, and neural changes associated with migraine onset. Aim 2b. To identify the temporal relationships between hormonal, psychophysical, and neural changes preced...
What is the current status of trial NCT05654012?
This trial is currently recruiting. It is a NA study. The enrollment target is 250 participants. The study started on 2023-06-01. Estimated completion is 2030-03-15.
What conditions does trial NCT05654012 study?
This clinical trial studies the following conditions: Migraine.
What interventions are being tested in trial NCT05654012?
The interventions under investigation include: MRI (DEVICE), Thermal Stimuli (DEVICE), Pressure stimuli (DEVICE), Pain ratings (BEHAVIORAL), Pressure pain thresholds (PPT) (BEHAVIORAL).
Who is sponsoring clinical trial NCT05654012?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05654012 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Migraine
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05654012's enrollment target sits among peer trials
250 36th of 102 higher than 67 of 102 other Migraine trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Migraine trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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