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NCT05626621 · ClinicalTrials.gov registry record · Phase 4

Efficacy of Azelastine and Mometasone Irrigation in Comparison to Nasal Sprays in Patients With Chronic Rhinitis

A Phase 4 study of Chronic Rhinitis, sponsored by Endeavor Health.

Recruiting
Registry status
Phase 4
Development phase
81
Enrollment target
1
Study location

NCT05626621 is a Phase 4 study of Chronic Rhinitis that is actively recruiting participants, run by Endeavor Health. The registered enrollment target is 81 participants, roughly in line with the 84-participant average among 6 other Chronic Rhinitis trials with a reported enrollment target. The trial reports 1 study location across 1 state.

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The verdict

NCT05626621, a Phase 4 study of Chronic Rhinitis, is actively recruiting participants, sponsored by Endeavor Health.

RECRUITING
Registry status
Phase 4
Development phase
81 participants
Enrollment target
1
Study location

Study Summary

The goal of this clinical trial is to determine the best combination of drugs and drug delivery routes to treat surgically naive chronic rhinitis patients. The main question it aims to answer is: Do high volume, high pressure delivery mechanisms in nasal irrigation improve the efficacy of azelastine combined with nasal steroid mometasone as compared to the standard low pressure, low volume delivery mechanisms in nasal sprays? Subjects will complete six months of one of three medication regimens: 1. Saline irrigation followed by azelastine spray and mometasone spray 2. Mometasone saline irrigation 3. Azelastine saline irrigation combined with mometasone saline irrigation.

Conditions Studied

Chronic Rhinitis

Interventions

  • DRUG Azelastine (137 mcg/spray) Nasal Spray and Mometasone (50 mcg/spray) Nasal Spray
  • DRUG Mometasone Nasal Irrigation (1 mg capsule)
  • DRUG Mometasone (1 mg) and Azelastine (1 mg) Nasal Irrigation

Study Locations (1)

Illinois

  • Northshore University HealthSystem - Evanston

Trial Details

FieldValue
Enrollment Target 81 participants
Start Date 2022-11-23
Est. Completion 2026-08
Phase Phase 4

Sponsor

Endeavor Health

94 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05626621

The ClinicalTrials.gov registry entry for NCT05626621 describes a study currently listed as recruiting, categorized as Phase 4. The registered enrollment target is 81 participants, a figure that helps gauge the scale of data the investigators plan to collect, roughly in line with the 84-participant average among 6 other Chronic Rhinitis trials with a reported enrollment target. The listed sponsor is Endeavor Health, which has 94 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Chronic Rhinitis appearing as the primary indexed condition, and to 3 interventions - of which Azelastine (137 mcg/spray) Nasal Spray and Mometasone (50 mcg/spray) Nasal Spray is the first listed.

NCT05626621 reports 1 study location spanning 1 distinct geographic area - top geographies include Illinois.

Frequently Asked Questions

What is clinical trial NCT05626621 about?

NCT05626621 is a clinical study titled "Efficacy of Azelastine and Mometasone Irrigation in Comparison to Nasal Sprays in Patients With Chronic Rhinitis". The goal of this clinical trial is to determine the best combination of drugs and drug delivery routes to treat surgically naive chronic rhinitis patients. The main question it aims to answer is: Do high volume, high pressure delivery mechanisms in nasal irrigation improve the efficacy of azelastin...

What is the current status of trial NCT05626621?

This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 81 participants. The study started on 2022-11-23. Estimated completion is 2026-08.

What conditions does trial NCT05626621 study?

This clinical trial studies the following conditions: Chronic Rhinitis.

What interventions are being tested in trial NCT05626621?

The interventions under investigation include: Azelastine (137 mcg/spray) Nasal Spray and Mometasone (50 mcg/spray) Nasal Spray (DRUG), Mometasone Nasal Irrigation (1 mg capsule) (DRUG), Mometasone (1 mg) and Azelastine (1 mg) Nasal Irrigation (DRUG).

Who is sponsoring clinical trial NCT05626621?

This trial is sponsored by Endeavor Health, which has 94 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05626621 being conducted?

This trial has 1 study location across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.