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NCT05617716 · ClinicalTrials.gov registry record · Phase 2
Spine Radiosurgery for Symptomatic Metastatic Neoplasms
A Phase 2 study of Metastatic Neoplasm and Metastatic Neoplasm to the Spine, sponsored by University of Oklahoma.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 240
- Enrollment target
- 2
- Study locations
NCT05617716: Recruiting Phase 2 study of Metastatic Neoplasm and Metastatic Neoplasm to the Spine, sponsored by University of Oklahoma.
NCT05617716 is a Phase 2 study of Metastatic Neoplasm and Metastatic Neoplasm to the Spine that is actively recruiting participants, run by University of Oklahoma. The registered enrollment target is 240 participants, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (80% higher). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05617716, a Phase 2 study of Metastatic Neoplasm and Metastatic Neoplasm to the Spine, is actively recruiting participants, sponsored by University of Oklahoma.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 240 participants
- Enrollment target
- 2
- Study locations
Study Summary
The purpose of this study is to compare three types of radiation therapy for cancer that has spread to the spine. The two types of radiation therapy used in this trial are External Beam Radiation Therapy (EBRT) and Stereotactic Body Radiation Therapy (SBRT). EBRT delivers tightly targeted radiation beams from outside the body. SBRT is a specialized type of radiation therapy that allows high doses of radiation to small targets. This study will include standard dose SBRT and higher dose SBRT. Each participant will be randomly assigned to either EBRT, standard dose SBRT, or higher dose SBRT.
Primary Outcome
Freedom from pain at 3 months defined as pain freedom following spine SBRT/EBRT per the Brief Pain Inventory (BPI), which is a scale of 1-10. The complete response for pain freedom is defined as a "worst" pain score of 0 on the BPI. Partial pain freedom is defined as a "worst" pain score of 2 points on the BPI.
Conditions Studied
Interventions
- RADIATION Conventional external beam radiation therapy dose (EBRT)
- RADIATION Spine radiosurgery/stereotactic body radiation therapy standard dose
- RADIATION Spine radiosurgery/stereotactic body radiation therapy high dose
Study Locations (2)
Maryland
- Johns Hopkins University Hospitals - Baltimore
Oklahoma
- OU Health Stephenson Cancer Center - Oklahoma City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 240 participants |
| Start Date | 2025-09-09 |
| Est. Completion | 2029-09-30 |
| Phase | Phase 2 |
What NCT05617716 shows while recruiting
NCT05617716 is an interventional study that assigns participants to a tested intervention. The registered 240 participants enrollment target is mid-sized for trials with a published cap, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (80% higher).
The record links to 2 conditions, with Metastatic Neoplasm appearing as the primary indexed condition, and to 3 interventions - of which Conventional external beam radiation therapy dose (EBRT) is the first listed.
NCT05617716 reports a single indexed study location in Maryland, Oklahoma.
Frequently Asked Questions
What is clinical trial NCT05617716 about?
NCT05617716 is a clinical study titled "Spine Radiosurgery for Symptomatic Metastatic Neoplasms". The purpose of this study is to compare three types of radiation therapy for cancer that has spread to the spine. The two types of radiation therapy used in this trial are External Beam Radiation Therapy (EBRT) and Stereotactic Body Radiation Therapy (SBRT). EBRT delivers tightly targeted radiation ...
What is the current status of trial NCT05617716?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 240 participants. The study started on 2025-09-09. Estimated completion is 2029-09-30.
What conditions does trial NCT05617716 study?
This clinical trial studies the following conditions: Metastatic Neoplasm, Metastatic Neoplasm to the Spine.
What interventions are being tested in trial NCT05617716?
The interventions under investigation include: Conventional external beam radiation therapy dose (EBRT) (RADIATION), Spine radiosurgery/stereotactic body radiation therapy standard dose (RADIATION), Spine radiosurgery/stereotactic body radiation therapy high dose (RADIATION).
Who is sponsoring clinical trial NCT05617716?
This trial is sponsored by University of Oklahoma, which has 358 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05617716 being conducted?
This trial has 2 study locations across Maryland, Oklahoma. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05617716's enrollment target sits among peer trials
240 239th of 2000 higher than 1,746 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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