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NCT05593965 · ClinicalTrials.gov registry record · NA
Causal Role of Frontostriatal Circuitry in Goal-directed Behavior
A NA study, sponsored by University of North Carolina, Chapel Hill.
- Completed
- Registry status
- NA
- Development phase
- 24
- Enrollment target
NCT05593965: Completed NA study, sponsored by University of North Carolina, Chapel Hill.
NCT05593965 is a NA study that has completed, run by University of North Carolina, Chapel Hill. The registered enrollment target is 24 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05593965, a NA study, has completed, sponsored by University of North Carolina, Chapel Hill.
- COMPLETED
- Registry status
- NA
- Development phase
- 24 participants
- Enrollment target
Study Summary
The purpose of this clinical trial is to investigate the causal role that frontostriatal circuitry plays in goal-directed behavior. The participants will perform a reward-based decision-making task. During the task, cross-frequency patterned rhythmic transcranial magnetic stimulation (TMS) will be delivered at delta-beta frequency, a control-frequency, or an active sham to either the dorsolateral or medial prefrontal cortex (PFC). Electroencephalography will be collected concurrent with stimulation. Structural and functional magnetic resonance imaging (MRI) will be collected during performance of the reward-based decision-making task to localize the stimulation targets.
Primary Outcome
In the Expenditure of Effort for Reward Task, participants are faced with a decision on every trial: to choose an easy task with a low effort exertion for a chance at winning a low amount of money and a hard task with a high effort exertion for a chance at winning a greater amount of money. The incentive for the high effort exertion is changed on each trial and the participant gets physically tired from repeated effort exertion. Goal-directed behavior was calculated as the percentage of trials i
Interventions
- DEVICE Arrhythmic TMS
- DEVICE Delta-beta TMS
- DEVICE Theta-gamma TMS
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2023-01-10 |
| Est. Completion | 2023-07-31 |
| Phase | NA |
What the finished NCT05593965 record still lists
NCT05593965 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 24 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 3 interventions - of which Arrhythmic TMS is the first listed.
NCT05593965 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05593965 about?
NCT05593965 is a clinical study titled "Causal Role of Frontostriatal Circuitry in Goal-directed Behavior". The purpose of this clinical trial is to investigate the causal role that frontostriatal circuitry plays in goal-directed behavior. The participants will perform a reward-based decision-making task. During the task, cross-frequency patterned rhythmic transcranial magnetic stimulation (TMS) will be d...
What is the current status of trial NCT05593965?
This trial is currently completed. It is a NA study. The enrollment target is 24 participants. The study started on 2023-01-10. Estimated completion is 2023-07-31.
What interventions are being tested in trial NCT05593965?
The interventions under investigation include: Arrhythmic TMS (DEVICE), Delta-beta TMS (DEVICE), Theta-gamma TMS (DEVICE).
Who is sponsoring clinical trial NCT05593965?
This trial is sponsored by University of North Carolina, Chapel Hill, which has 1,109 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05593965's enrollment target sits among peer trials
24 1736th of 2000 higher than 246 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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