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NCT05591404 · ClinicalTrials.gov registry record · NA
Investigating the Effects of Social Stress on Brain Imaging
A NA study of Social Stress, sponsored by Massachusetts Institute of Technology.
- Recruiting
- Registry status
- NA
- Development phase
- 50
- Enrollment target
- 1
- Study location
NCT05591404: Recruiting NA study of Social Stress, sponsored by Massachusetts Institute of Technology.
NCT05591404 is a NA study of Social Stress that is actively recruiting participants, run by Massachusetts Institute of Technology. The registered enrollment target is 50 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05591404, a NA study of Social Stress, is actively recruiting participants, sponsored by Massachusetts Institute of Technology.
- RECRUITING
- Registry status
- NA
- Development phase
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to examine whether experiencing a social stressor prior to the collection of neuroimaging measures is associated with differences in brain activation in healthy participants.
Primary Outcome
Patterns of brain activation measured as blood-oxygenation-level dependent (BOLD) signals will be assessed using 3.0 Tesla (3T) functional magnetic resonance imaging (fMRI). Several exploratory imaging paradigms, including the emotional face-matching task (EFMT) and the self-referential comment task (SRCT), will be used to examine differences between participants who experience the TSST and those who do not.
Conditions Studied
Interventions
- BEHAVIORAL Trier Social Stress Test (TSST)
Study Locations (1)
Massachusetts
- Massachusetts Institute of Technology - Cambridge
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2025-11-17 |
| Est. Completion | 2026-11 |
| Phase | NA |
What NCT05591404 shows while recruiting
NCT05591404 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower).
The record links to 1 condition, with Social Stress appearing as the primary indexed condition, and to 1 intervention - of which Trier Social Stress Test (TSST) is the first listed.
NCT05591404 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT05591404 about?
NCT05591404 is a clinical study titled "Investigating the Effects of Social Stress on Brain Imaging". The purpose of this study is to examine whether experiencing a social stressor prior to the collection of neuroimaging measures is associated with differences in brain activation in healthy participants.
What is the current status of trial NCT05591404?
This trial is currently recruiting. It is a NA study. The enrollment target is 50 participants. The study started on 2025-11-17. Estimated completion is 2026-11.
What conditions does trial NCT05591404 study?
This clinical trial studies the following conditions: Social Stress.
What interventions are being tested in trial NCT05591404?
The interventions under investigation include: Trier Social Stress Test (TSST) (BEHAVIORAL).
Who is sponsoring clinical trial NCT05591404?
This trial is sponsored by Massachusetts Institute of Technology, which has 24 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05591404 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Social Stress
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05591404's enrollment target sits among peer trials
50 1279th of 2000 higher than 622 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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