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NCT05563779 · ClinicalTrials.gov registry record · NA
Mode Of Ventilation During Critical IllnEss Pilot Trial
A NA study, sponsored by Vanderbilt University Medical Center.
- Completed
- Registry status
- NA
- Development phase
- 566
- Enrollment target
NCT05563779: Completed NA study, sponsored by Vanderbilt University Medical Center.
NCT05563779 is a NA study that has completed, run by Vanderbilt University Medical Center. The registered enrollment target is 566 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (60% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05563779, a NA study, has completed, sponsored by Vanderbilt University Medical Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 566 participants
- Enrollment target
Study Summary
Landmark trials in critical care have demonstrated that, among critically ill adults receiving invasive mechanical ventilation, the use of low tidal volumes and low airway pressures prevents lung injury and improves patient outcomes. Limited evidence, however, informs the best method of mechanical ventilation to achieve these targets. To provide mechanical ventilation, clinicians must choose between modes of ventilation that directly control tidal volumes ("volume control"), modes that directly control the inspiratory airway pressure ("pressure control"), and modes that are hybrids ("adaptive pressure control"). Whether the choice of the mode used to target low tidal volumes and low inspiratory plateau pressures affects clinical outcomes for critically ill adults receiving mechanical ventilation is unknown. All three modes of mechanical ventilation are commonly used in clinical practice. A large, multicenter randomized trial comparing available modes of mechanical ventilation is needed to understand the effect of each mode on clinical outcomes. The investigators propose a 9-month cluster-randomized cluster-crossover pilot trial evaluating the feasibility of comparing three modes (volume control, pressure control, and adaptive pressure control) for mechanically ventilated ICU patients with regard to the outcome of days alive and free of invasive mechanical ventilation.
Primary Outcome
Number of days alive and free from invasive mechanical ventilation between the final liberation from invasive mechanical ventilation before 28 days and study day 28. Patients who continue to receive invasive mechanical ventilation at day 28 or have died prior to day 28 will receive zero VFDs. For patients who return to invasive mechanical ventilation and are subsequently liberated from invasive mechanical ventilation prior to day 28, VFDs will be counted from final liberation from mechanical ven
Interventions
- OTHER Volume Control mode
- OTHER Pressure Control mode
- OTHER Adaptive Pressure Control mode
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 566 participants |
| Start Date | 2022-11-01 |
| Est. Completion | 2023-08-28 |
| Phase | NA |
What the finished NCT05563779 record still lists
NCT05563779 is an interventional study that assigns participants to a tested intervention. The registered 566 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (60% lower).
The record links to 0 conditions, and to 3 interventions - of which Volume Control mode is the first listed.
NCT05563779 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05563779 about?
NCT05563779 is a clinical study titled "Mode Of Ventilation During Critical IllnEss Pilot Trial". Landmark trials in critical care have demonstrated that, among critically ill adults receiving invasive mechanical ventilation, the use of low tidal volumes and low airway pressures prevents lung injury and improves patient outcomes. Limited evidence, however, informs the best method of mechanical v...
What is the current status of trial NCT05563779?
This trial is currently completed. It is a NA study. The enrollment target is 566 participants. The study started on 2022-11-01. Estimated completion is 2023-08-28.
What interventions are being tested in trial NCT05563779?
The interventions under investigation include: Volume Control mode (OTHER), Pressure Control mode (OTHER), Adaptive Pressure Control mode (OTHER).
Who is sponsoring clinical trial NCT05563779?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05563779's enrollment target sits among peer trials
566 180th of 2000 higher than 1,821 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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