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NCT05558371 · ClinicalTrials.gov registry record
International CDKL5 Clinical Research Network
A clinical trial of CDKL5 Deficiency Disorder and CDKL5, sponsored by University of Colorado, Denver.
- Recruiting
- Registry status
- 1,000
- Enrollment target
- 9
- Study locations
NCT05558371 is a study of CDKL5 Deficiency Disorder and CDKL5 that is actively recruiting participants, run by University of Colorado, Denver. The registered enrollment target is 1,000 participants. The trial reports 9 study locations across 9 states.
The verdict
NCT05558371, a study of CDKL5 Deficiency Disorder and CDKL5, is actively recruiting participants, sponsored by University of Colorado, Denver.
- RECRUITING
- Registry status
- 1,000 participants
- Enrollment target
- 9
- Study locations
Study Summary
Pathogenic variants in the Cyclin-dependent kinase like 5 (CDKL5) gene cause CDKL5 deficiency disorder (CDD, MIM 300672, 105830), a severe developmental and epileptic encephalopathy associated with cognitive and motor impairments and cortical visual impairment. While capability for disease modifying therapies is accelerating, there is a critical barrier for clinical trial readiness that may result in failure of these therapies, not due to lack of efficacy but due to lack of validated outcome measures and biomarkers. The measures and biomarkers validated here will be adaptable to other developmental and epileptic encephalopathies.
Conditions Studied
Interventions
- OTHER No intervention.
Study Locations (9)
California
- University of California Los Angeles/UCLA Mattel Children's Hospital - Los Angeles
Colorado
- University of Colorado Denver/Children's Hospital Colorado - Aurora
Massachusetts
- Harvard Medical School/Boston Children's Hospital - Boston
Missouri
- Washington University in St. Louis/St. Louis Children's Hospital - St Louis
New York
- NYU Langone Health - New York
Ohio
- Cleveland Clinic Foundation - Cleveland
Pennsylvania
- Children's Hospital of Philadelphia - Philadelphia
Texas
- Baylor College of Medicine/ Texas Children's Hospital - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,000 participants |
| Start Date | 2021-02-15 |
| Est. Completion | 2027-02-15 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05558371
The ClinicalTrials.gov registry entry for NCT05558371 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 1,000 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Colorado, Denver, which has 1,283 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with CDKL5 Deficiency Disorder appearing as the primary indexed condition, and to 1 intervention - of which No intervention. is the first listed.
NCT05558371 reports 9 study locations spanning 9 distinct geographic areas - top geographies include California, Colorado, Massachusetts.
Frequently Asked Questions
What is clinical trial NCT05558371 about?
NCT05558371 is a clinical study titled "International CDKL5 Clinical Research Network". Pathogenic variants in the Cyclin-dependent kinase like 5 (CDKL5) gene cause CDKL5 deficiency disorder (CDD, MIM 300672, 105830), a severe developmental and epileptic encephalopathy associated with cognitive and motor impairments and cortical visual impairment. While capability for disease modifying...
What is the current status of trial NCT05558371?
This trial is currently recruiting. The enrollment target is 1,000 participants. The study started on 2021-02-15. Estimated completion is 2027-02-15.
What conditions does trial NCT05558371 study?
This clinical trial studies the following conditions: CDKL5 Deficiency Disorder, CDKL5, CDD.
What interventions are being tested in trial NCT05558371?
The interventions under investigation include: No intervention. (OTHER).
Who is sponsoring clinical trial NCT05558371?
This trial is sponsored by University of Colorado, Denver, which has 1,283 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05558371 being conducted?
This trial has 9 study locations across California, Colorado, Massachusetts, Missouri, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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