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NCT05540860 · ClinicalTrials.gov registry record · Phase 2
A Study of EDG-5506 in Children With Duchenne Muscular Dystrophy (LYNX)
A Phase 2 study of Duchenne Muscular Dystrophy, sponsored by Edgewise Therapeutics.
- Active
- Registry status
- Phase 2
- Development phase
- 76
- Enrollment target
- 14
- Study locations
NCT05540860: Active Phase 2 study of Duchenne Muscular Dystrophy, sponsored by Edgewise Therapeutics.
NCT05540860 is a Phase 2 study of Duchenne Muscular Dystrophy that is active but no longer recruiting, run by Edgewise Therapeutics. The registered enrollment target is 76 participants, below the 411-participant average among 48 other Duchenne Muscular Dystrophy trials with a reported enrollment target (82% lower). The trial reports 14 study locations across 12 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05540860, a Phase 2 study of Duchenne Muscular Dystrophy, is active but no longer recruiting, sponsored by Edgewise Therapeutics.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 76 participants
- Enrollment target
- 14
- Study locations
Study Summary
The LYNX study is a 2-part, multicenter, Phase 2 study of safety, pharmacokinetics and biomarkers in children with Duchenne muscular dystrophy including a randomized, double-blind, placebo-controlled part A, followed by an open-label part B.
Primary Outcome
All participants
Conditions Studied
Interventions
- DRUG Sevasemten Dose 1
- DRUG Sevasemten Dose 2
- DRUG Sevasemten Dose 3
- DRUG Sevasemten Dose 4
- DRUG Sevasemten Dose 5
Study Locations (14)
California
- UCLA Medical Center - Los Angeles
- UC Davis Medical Center - Sacramento
Ohio
- Cincinnati Children's Hospital - Cincinnati
- Nationwide Children's Hospital - Columbus
Arkansas
- Arkansas Children's Hospital - Little Rock
Colorado
- Children's Hospital Colorado - Aurora
Florida
- University of Florida - Gainesville
Georgia
- Rare Disease Research - Atlanta
Iowa
- University of Iowa - Iowa City
Kansas
- University of Kansas Medical Center - Kansas City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 76 participants |
| Start Date | 2022-10-24 |
| Est. Completion | 2027-01 |
| Phase | Phase 2 |
What the registry record for NCT05540860 still lists
NCT05540860 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 76 participants, a relatively small participant target, below the 411-participant average among 48 other Duchenne Muscular Dystrophy trials with a reported enrollment target (82% lower).
The record links to 1 condition, with Duchenne Muscular Dystrophy appearing as the primary indexed condition, and to 5 interventions - of which Sevasemten Dose 1 is the first listed.
NCT05540860 lists 14 locations in 12 states (California, Ohio, Arkansas).
Frequently Asked Questions
What is clinical trial NCT05540860 about?
NCT05540860 is a clinical study titled "A Study of EDG-5506 in Children With Duchenne Muscular Dystrophy (LYNX)". The LYNX study is a 2-part, multicenter, Phase 2 study of safety, pharmacokinetics and biomarkers in children with Duchenne muscular dystrophy including a randomized, double-blind, placebo-controlled part A, followed by an open-label part B.
What is the current status of trial NCT05540860?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 76 participants. The study started on 2022-10-24. Estimated completion is 2027-01.
What conditions does trial NCT05540860 study?
This clinical trial studies the following conditions: Duchenne Muscular Dystrophy.
What interventions are being tested in trial NCT05540860?
The interventions under investigation include: Sevasemten Dose 1 (DRUG), Sevasemten Dose 2 (DRUG), Sevasemten Dose 3 (DRUG), Sevasemten Dose 4 (DRUG), Sevasemten Dose 5 (DRUG).
Who is sponsoring clinical trial NCT05540860?
This trial is sponsored by Edgewise Therapeutics, which has 15 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05540860 being conducted?
This trial has 14 study locations across Arkansas, California, Colorado, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Duchenne Muscular Dystrophy
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05540860's enrollment target sits among peer trials
76 16th of 48 higher than 33 of 48 other Duchenne Muscular Dystrophy trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Duchenne Muscular Dystrophy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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