Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05526586 · ClinicalTrials.gov registry record · Phase 4
A Twelve Week Study of Prototypes Mouth Rinses
A Phase 4 study, sponsored by Johnson & Johnson Consumer Inc. (J&JCI).
- Completed
- Registry status
- Phase 4
- Development phase
- 192
- Enrollment target
NCT05526586: Completed Phase 4 study, sponsored by Johnson & Johnson Consumer Inc. (J&JCI).
NCT05526586 is a Phase 4 study that has completed, run by Johnson & Johnson Consumer Inc. (J&JCI). The registered enrollment target is 192 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (63% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05526586, a Phase 4 study, has completed, sponsored by Johnson & Johnson Consumer Inc. (J&JCI).
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 192 participants
- Enrollment target
Study Summary
The purpose of this study is to evaluate the safety and efficacy of two essential oil containing experimental mouth rinse formulations and an essential oil containing mouth rinse compared to a hydroalcohol control mouth rinse for the reduction of gingivitis and plaque when used as an adjunct to tooth brushing during a twelve-week product usage period.
Primary Outcome
Gingivitis will be assessed by the MGI on the buccal and lingual marginal gingivae and interdental papillae of all scorable teeth: 0 (Normal \[absence of inflammation\]), 1 (Mild inflammation \[slight change in color, little change in texture\] of any portion of the entire gingival unit); 2 (Mild inflammation of the entire gingival unit); 3 (Moderate inflammation \[moderate glazing, redness, edema, and/or hypertrophy\] of the gingival unit); 4 (Severe inflammation \[marked redness and edema/hype
Interventions
- OTHER Colgate Cavity Protection Toothpaste
- OTHER Zero Alcohol Gum Prototype
- OTHER Alcohol Gum Prototype
- OTHER Listerine Cool Mint Antiseptic Mouthwash
- OTHER 5% Hydroalcohol
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 192 participants |
| Start Date | 2022-08-31 |
| Est. Completion | 2022-12-08 |
| Phase | Phase 4 |
What the finished NCT05526586 record still lists
NCT05526586 is an interventional study that assigns participants to a tested intervention. The registered 192 participants enrollment target is mid-sized for trials with a published cap, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (63% lower).
The record links to 0 conditions, and to 5 interventions - of which Colgate Cavity Protection Toothpaste is the first listed.
NCT05526586 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05526586 about?
NCT05526586 is a clinical study titled "A Twelve Week Study of Prototypes Mouth Rinses". The purpose of this study is to evaluate the safety and efficacy of two essential oil containing experimental mouth rinse formulations and an essential oil containing mouth rinse compared to a hydroalcohol control mouth rinse for the reduction of gingivitis and plaque when used as an adjunct to toot...
What is the current status of trial NCT05526586?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 192 participants. The study started on 2022-08-31. Estimated completion is 2022-12-08.
What interventions are being tested in trial NCT05526586?
The interventions under investigation include: Colgate Cavity Protection Toothpaste (OTHER), Zero Alcohol Gum Prototype (OTHER), Alcohol Gum Prototype (OTHER), Listerine Cool Mint Antiseptic Mouthwash (OTHER), 5% Hydroalcohol (OTHER).
Who is sponsoring clinical trial NCT05526586?
This trial is sponsored by Johnson & Johnson Consumer Inc. (J&JCI), which has 40 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05526586's enrollment target sits among peer trials
192 451st of 2000 higher than 1,548 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01492972 · 192 participants · Phase 3
Hypo-fractionated Radiation Therapy With or Without Androgen Suppression for Intermediate Risk Prostate Cancer
- NCT01973881 · 192 participants
Quantitative MRI for Myelofibrosis
- NCT02535702 · 192 participants · NA
Development Of Neuroimaging Methods To Assess The Neurobiology Of Addiction
- NCT03622359 · 192 participants · NA
Radiotracer-Based Perfusion Imaging of Patients With Peripheral Arterial Disease
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI