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COMPLETED Phase 2

A Study of Coformulated Favezelimab/Pembrolizumab (MK-4280A) Versus Physician's Choice Chemotherapy in PD-(L)1-refractory, Relapsed or Refractory Classical Hodgkin Lymphoma (MK-4280A-008)

NCT05508867 · View on ClinicalTrials.gov ↗

Study Summary

Researchers are looking for a way to treat classical Hodgkin lymphoma (cHL) that is relapsed (the cancer has come back after treatment) or refractory (current treatment has stopped working to slow or stop cancer growth). Researchers want to learn if people who receive coformulated favezelimab/pembrolizumab (MK-4280A) live longer without the cancer getting worse compared to those who receive chemotherapy.

Conditions Studied

Interventions

  • DRUG gemcitabine
  • DRUG bendamustine
  • BIOLOGICAL favezelimab/pembrolizumab

Study Locations (20)

California

  • UCLA Hematology/Oncology - Santa Monica ( Site 2208) — Los Angeles
  • Lundquist Institute for Biomedical Innovation at Harbor-UCLA-Hematology and Medical Oncology ( Site — Torrance

Maryland

  • University of Maryland-Greenebaum Comprehensive Cancer Center ( Site 2210) — Baltimore
  • Johns Hopkins University-The Sidney Kimmel Comprehensive Cancer Center ( Site 2206) — Baltimore

Michigan

  • University of Michigan ( Site 2215) — Ann Arbor
  • Cancer and Hematology Centers of Western Michigan ( Site 2222) — Grand Rapids

Ohio

  • University Hospitals Cleveland Medical Center ( Site 2214) — Cleveland
  • Cleveland Clinic-Taussig Cancer Center ( Site 2203) — Cleveland

Pennsylvania

  • AHN West Penn Hospital ( Site 2213) — Pittsburgh
  • UPMC Hillman Cancer Center ( Site 2205) — Pittsburgh

Other

  • Hospital Aleman-oncohematologic diseases ( Site 2302) — Buenos Aires
  • Fundacion Centro Oncologico de Integración Regional-Medical Oncology ( Site 2301) — Mendoza

Arizona

  • The University of Arizona Cancer Center - North Campus ( Site 2216) — Tucson

Florida

  • Moffitt Cancer Center ( Site 2200) — Tampa

Trial Details

FieldValue
Enrollment Target 203 participants
Start Date 2022-10-18
Est. Completion 2026-01-08
Phase Phase 2

Sponsor

Merck Sharp & Dohme

741 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05508867

The ClinicalTrials.gov registry entry for NCT05508867 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 203 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Merck Sharp & Dohme, which has 741 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Hodgkin Lymphoma appearing as the primary indexed condition, and to 3 interventions — of which gemcitabine is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05508867 reports 20 study locations spanning 14 distinct geographic areas — top geographies include California, Maryland, Michigan. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05508867 about?

NCT05508867 is a clinical study titled "A Study of Coformulated Favezelimab/Pembrolizumab (MK-4280A) Versus Physician's Choice Chemotherapy in PD-(L)1-refractory, Relapsed or Refractory Classical Hodgkin Lymphoma (MK-4280A-008)". Researchers are looking for a way to treat classical Hodgkin lymphoma (cHL) that is relapsed (the cancer has come back after treatment) or refractory (current treatment has stopped working to slow or stop cancer growth). Researchers want to learn if people who receive coformulated favezelimab/pembro...

What is the current status of trial NCT05508867?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 203 participants. The study started on 2022-10-18. Estimated completion is 2026-01-08.

What conditions does trial NCT05508867 study?

This clinical trial studies the following conditions: Hodgkin Lymphoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05508867?

The interventions under investigation include: gemcitabine (DRUG), bendamustine (DRUG), favezelimab/pembrolizumab (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05508867?

This trial is sponsored by Merck Sharp & Dohme, which has 741 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05508867 being conducted?

This trial has 20 study locations across Arizona, California, Florida, Kentucky, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial