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NCT05486559 · ClinicalTrials.gov registry record · NA
The ECMO-Free Trial
A NA study of Extracorporeal Membrane Oxygenation Complication, sponsored by Vanderbilt University Medical Center.
- Active
- Registry status
- NA
- Development phase
- 225
- Enrollment target
- 8
- Study locations
NCT05486559 is a NA study of Extracorporeal Membrane Oxygenation Complication that is active but no longer recruiting, run by Vanderbilt University Medical Center. The registered enrollment target is 225 participants, below the 810-participant average among 8 other Extracorporeal Membrane Oxygenation Complication trials with a reported enrollment target (72% lower). The trial reports 8 study locations across 6 states.
The verdict
NCT05486559, a NA study of Extracorporeal Membrane Oxygenation Complication, is active but no longer recruiting, sponsored by Vanderbilt University Medical Center.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 225 participants
- Enrollment target
- 8
- Study locations
Study Summary
Decannulation from venovenous extracorporeal membrane oxygenation (VV-ECMO) at the earliest and safest time would be expected to improve outcomes and reduce cost. Daily assessments for readiness to liberate from therapies have demonstrated success in other realms of critical care. A recent single-center study demonstrated that a protocolized daily assessment of readiness for liberation from VV-ECMO was feasible and did not raise any major safety concerns, but the effect of this protocolized daily assessment on clinical outcomes remains unclear. Further, the manner in which ECMO is provided, weaned, and discontinued varies significantly between centers, raising persistent concerns regarding widespread adoption of protocolized daily assessment of readiness for liberation from VV-ECMO. Data from large a randomized controlled trial is needed to compare the effects of a protocolized daily assessment of readiness for liberation from VV-ECMO versus usual care on duration of ECMO support and other clinical outcomes.
Conditions Studied
Interventions
- OTHER Usual Care
- OTHER ECMO-free protocol
Study Locations (8)
California
- UC San Diego Health - San Diego
- Stanford University - Stanford
Texas
- Baylor University Medical Center - Dallas
- Texas Tech University Health Sciences Center of El Paso - El Paso
Minnesota
- Hennepin County Medical Center - Minneapolis
Tennessee
- Vanderbilt University Medical Center - Nashville
Utah
- University of Utah Health - Salt Lake City
Ontario
- Toronto General Hospital - Toronto
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 225 participants |
| Start Date | 2022-09-07 |
| Est. Completion | 2026-04-18 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05486559
The ClinicalTrials.gov registry entry for NCT05486559 describes a study currently listed as active not recruiting, categorized as NA. The registered enrollment target is 225 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 810-participant average among 8 other Extracorporeal Membrane Oxygenation Complication trials with a reported enrollment target (72% lower). The listed sponsor is Vanderbilt University Medical Center, which has 677 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Extracorporeal Membrane Oxygenation Complication appearing as the primary indexed condition, and to 2 interventions - of which Usual Care is the first listed.
NCT05486559 reports 8 study locations spanning 6 distinct geographic areas - top geographies include California, Texas, Minnesota.
Frequently Asked Questions
What is clinical trial NCT05486559 about?
NCT05486559 is a clinical study titled "The ECMO-Free Trial". Decannulation from venovenous extracorporeal membrane oxygenation (VV-ECMO) at the earliest and safest time would be expected to improve outcomes and reduce cost. Daily assessments for readiness to liberate from therapies have demonstrated success in other realms of critical care. A recent single-ce...
What is the current status of trial NCT05486559?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 225 participants. The study started on 2022-09-07. Estimated completion is 2026-04-18.
What conditions does trial NCT05486559 study?
This clinical trial studies the following conditions: Extracorporeal Membrane Oxygenation Complication.
What interventions are being tested in trial NCT05486559?
The interventions under investigation include: Usual Care (OTHER), ECMO-free protocol (OTHER).
Who is sponsoring clinical trial NCT05486559?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05486559 being conducted?
This trial has 8 study locations across California, Minnesota, Tennessee, Texas, Utah. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
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