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NCT05470517 · ClinicalTrials.gov registry record · Phase 2
Antibiotic Instillation in Appendicitis
A Phase 2 study, sponsored by Johns Hopkins All Children's Hospital.
- Completed
- Registry status
- Phase 2
- Development phase
- 190
- Enrollment target
NCT05470517: Completed Phase 2 study, sponsored by Johns Hopkins All Children's Hospital.
NCT05470517 is a Phase 2 study that has completed, run by Johns Hopkins All Children's Hospital. The registered enrollment target is 190 participants, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (43% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05470517, a Phase 2 study, has completed, sponsored by Johns Hopkins All Children's Hospital.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 190 participants
- Enrollment target
Study Summary
Appendicitis (inflammation of the wall of the appendix, causing pain and tenderness in the abdomen) has a range of severity that goes from simple to complicated. Complicated appendicitis may present with infected fluid inside of the abdomen or a perforation or hole in the intestines. This research is being done to determine if placing an antibiotic solution in the abdomen at the time the appendix is removed is a safe procedure in patients between the ages of 3 and 18 years old with findings of complicated appendicitis. Johns Hopkins All Children's Hospital (JHACH)'s current standard of care for patients with complicated appendicitis includes suctioning the infected fluid out of the abdomen at the time the appendix is removed. As part of this study, the investigators would like to see if patients with complicated appendicitis will benefit from routine care plus leaving an antibiotic solution inside the abdomen, after fully suctioning the infected fluid out of the abdomen.
Primary Outcome
The study will be deemed feasible if \>50% of potential participants agree to participate. This benchmark is based on a previous similar study completed in this population.
Interventions
- DRUG Ceftriaxone
- PROCEDURE Intra-peritoneal Fluid Aspiration
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 190 participants |
| Start Date | 2023-01-05 |
| Est. Completion | 2024-03-20 |
| Phase | Phase 2 |
What the finished NCT05470517 record still lists
NCT05470517 is an interventional study that assigns participants to a tested intervention. The registered 190 participants enrollment target is mid-sized for trials with a published cap, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (43% higher).
The record links to 0 conditions, and to 2 interventions - of which Ceftriaxone is the first listed.
NCT05470517 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05470517 about?
NCT05470517 is a clinical study titled "Antibiotic Instillation in Appendicitis". Appendicitis (inflammation of the wall of the appendix, causing pain and tenderness in the abdomen) has a range of severity that goes from simple to complicated. Complicated appendicitis may present with infected fluid inside of the abdomen or a perforation or hole in the intestines. This research ...
What is the current status of trial NCT05470517?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 190 participants. The study started on 2023-01-05. Estimated completion is 2024-03-20.
What interventions are being tested in trial NCT05470517?
The interventions under investigation include: Ceftriaxone (DRUG), Intra-peritoneal Fluid Aspiration (PROCEDURE).
Who is sponsoring clinical trial NCT05470517?
This trial is sponsored by Johns Hopkins All Children's Hospital, which has 24 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05470517's enrollment target sits among peer trials
190 353rd of 2000 higher than 1,646 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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