Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05465382 · ClinicalTrials.gov registry record · NA
Effect of Early Saline Lavage on Synovial Fluid Composition Following Intra Articular Ankle Fractures
A NA study, sponsored by Duke University.
- Terminated
- Registry status
- NA
- Development phase
- 41
- Enrollment target
NCT05465382: Clinical Trial NA study, sponsored by Duke University.
NCT05465382 is a NA study that was terminated before completion, run by Duke University. The registered enrollment target is 41 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05465382, a NA study, was terminated before completion, sponsored by Duke University.
- TERMINATED
- Registry status
- NA
- Development phase
- 41 participants
- Enrollment target
Study Summary
The purpose of this study is to examine the effect of early, percutaneous, intra-articular saline lavage on the undiluted synovial fluid microenvironment during the acute phase following intra-articular fracture of the human ankle. We hypothesize that early intervention with percutaneous joint lavage in the first 0-48 hours after injury will attenuate the production of pro-inflammatory cytokines, MMP's and cartilage breakdown products compared to non-lavaged control subjects at the time of surgical fixation.
Primary Outcome
Reported as the total change between baseline and 1 to 2 weeks post-injury.
Interventions
- DEVICE Saline Lavage
- OTHER No intra-articular saline lavage
- DRUG Lidocaine - intra-articular injection
- OTHER Synovial Fluid Aspiration
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 41 participants |
| Start Date | 2022-07-22 |
| Est. Completion | 2024-05-07 |
| Phase | NA |
Why NCT05465382 stopped before completion
NCT05465382 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 41 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 4 interventions - of which Saline Lavage is the first listed.
NCT05465382 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05465382 about?
NCT05465382 is a clinical study titled "Effect of Early Saline Lavage on Synovial Fluid Composition Following Intra Articular Ankle Fractures". The purpose of this study is to examine the effect of early, percutaneous, intra-articular saline lavage on the undiluted synovial fluid microenvironment during the acute phase following intra-articular fracture of the human ankle. We hypothesize that early intervention with percutaneous joint lavag...
What is the current status of trial NCT05465382?
This trial is currently terminated. It is a NA study. The enrollment target is 41 participants. The study started on 2022-07-22. Estimated completion is 2024-05-07.
What interventions are being tested in trial NCT05465382?
The interventions under investigation include: Saline Lavage (DEVICE), No intra-articular saline lavage (OTHER), Lidocaine - intra-articular injection (DRUG), Synovial Fluid Aspiration (OTHER).
Who is sponsoring clinical trial NCT05465382?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05465382's enrollment target sits among peer trials
41 1446th of 2000 higher than 554 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT03449238 · 41 participants · Phase 1
Pembrolizumab And Stereotactic Radiosurgery (Srs) Of Selected Brain Metastases In Breast Cancer Patients
- NCT03900793 · 41 participants · Phase 1
Losartan + Sunitinib in Treatment of Osteosarcoma
- NCT04082520 · 41 participants · Phase 2
Lutathera for the Treatment of Inoperable, Progressive Meningioma After External Beam Radiation Therapy
- NCT04220190 · 41 participants · Phase 2
RAPA-501 Therapy for ALS
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI