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NCT05459129 · ClinicalTrials.gov registry record · Phase 1
A Study Evaluating Efficacy and Safety of Multiple Treatment Combinations in Patients With Locally Advanced Squamous Cell Carcinoma of the Head and Neck (Morpheus-Head and Neck Cancer)
A Phase 1 study, sponsored by Hoffmann-La Roche.
- Completed
- Registry status
- Phase 1
- Development phase
- 12
- Enrollment target
NCT05459129 is a Phase 1 study that has completed, run by Hoffmann-La Roche. The registered enrollment target is 12 participants.
The verdict
NCT05459129, a Phase 1 study, has completed, sponsored by Hoffmann-La Roche.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 12 participants
- Enrollment target
Study Summary
This is a Phase Ib/II, open-label, multicenter, randomized, umbrella study in participants with locally advanced squamous cell carcinoma of the head and neck (SCCHN). The study will enroll treatment-naive participants with resectable Stage III-IVA human papillomavirus (HPV)-negative, programmed death-ligand 1 (PD-L1)-positive SCCHN with measurable disease, as assessed by the investigator according to Response Evaluation Criteria in Solid Tumors, Version 1.1 (RECIST v1.1) who have not received systemic treatment for their disease.
Interventions
- DRUG Carboplatin
- DRUG Atezolizumab
- DRUG Paclitaxel
- DRUG Tiragolumab
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 12 participants |
| Start Date | 2023-04-12 |
| Est. Completion | 2024-08-15 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05459129
The ClinicalTrials.gov registry entry for NCT05459129 describes a study currently listed as completed, categorized as Phase 1. The registered enrollment target is 12 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Hoffmann-La Roche, which has 909 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 4 interventions - of which Carboplatin is the first listed.
NCT05459129 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT05459129 about?
NCT05459129 is a clinical study titled "A Study Evaluating Efficacy and Safety of Multiple Treatment Combinations in Patients With Locally Advanced Squamous Cell Carcinoma of the Head and Neck (Morpheus-Head and Neck Cancer)". This is a Phase Ib/II, open-label, multicenter, randomized, umbrella study in participants with locally advanced squamous cell carcinoma of the head and neck (SCCHN). The study will enroll treatment-naive participants with resectable Stage III-IVA human papillomavirus (HPV)-negative, programmed deat...
What is the current status of trial NCT05459129?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 12 participants. The study started on 2023-04-12. Estimated completion is 2024-08-15.
What interventions are being tested in trial NCT05459129?
The interventions under investigation include: Carboplatin (DRUG), Atezolizumab (DRUG), Paclitaxel (DRUG), Tiragolumab (DRUG).
Who is sponsoring clinical trial NCT05459129?
This trial is sponsored by Hoffmann-La Roche, which has 909 total clinical trials registered on ClinicalTrials.gov.
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