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NCT05451953 · ClinicalTrials.gov registry record · NA
Providing Oxygen During Intubation in the NICU Trial
A NA study of Neonatal Respiratory Failure and Tracheal Intubation Morbidity, sponsored by University of Pennsylvania.
- Recruiting
- Registry status
- NA
- Development phase
- 110
- Enrollment target
- 1
- Study location
NCT05451953: Recruiting NA study of Neonatal Respiratory Failure and Tracheal Intubation Morbidity, sponsored by University of Pennsylvania.
NCT05451953 is a NA study of Neonatal Respiratory Failure and Tracheal Intubation Morbidity that is actively recruiting participants, run by University of Pennsylvania. The registered enrollment target is 110 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (92% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05451953, a NA study of Neonatal Respiratory Failure and Tracheal Intubation Morbidity, is actively recruiting participants, sponsored by University of Pennsylvania.
- RECRUITING
- Registry status
- NA
- Development phase
- 110 participants
- Enrollment target
- 1
- Study location
Study Summary
Tracheal intubation in the NICU is frequently complicated by severe oxygen desaturation. Apneic oxygenation, a method of applying free flowing oxygen via nasal cannula to apneic patients undergoing intubation, prevents or delays oxygen desaturation during intubation in adults and older children. We propose to enroll patients at two sites (Hospital of the University of Pennsylvania and Children's Hospital of Philadelphia) in a randomized trial in infants undergoing intubation in the NICU to determine if apneic oxygenation, compared with no respiratory support or oxygen during laryngoscopy and intubation attempts (standard care), reduces the magnitude of oxygen desaturation during tracheal intubation encounters.
Primary Outcome
Difference between highest SpO2 immediately prior to first intubation attempt and lowest SpO2 during the intubation encounter.
Conditions Studied
Interventions
- PROCEDURE Standard of Care
- PROCEDURE Apneic Oxygenation
Study Locations (1)
Pennsylvania
- University of Pennsylvania - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 110 participants |
| Start Date | 2022-07-20 |
| Est. Completion | 2027-02-28 |
| Phase | NA |
What NCT05451953 shows while recruiting
NCT05451953 is an interventional study that assigns participants to a tested intervention. The registered 110 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (92% lower).
The record links to 2 conditions, with Neonatal Respiratory Failure appearing as the primary indexed condition, and to 2 interventions - of which Standard of Care is the first listed.
NCT05451953 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT05451953 about?
NCT05451953 is a clinical study titled "Providing Oxygen During Intubation in the NICU Trial". Tracheal intubation in the NICU is frequently complicated by severe oxygen desaturation. Apneic oxygenation, a method of applying free flowing oxygen via nasal cannula to apneic patients undergoing intubation, prevents or delays oxygen desaturation during intubation in adults and older children. We ...
What is the current status of trial NCT05451953?
This trial is currently recruiting. It is a NA study. The enrollment target is 110 participants. The study started on 2022-07-20. Estimated completion is 2027-02-28.
What conditions does trial NCT05451953 study?
This clinical trial studies the following conditions: Neonatal Respiratory Failure, Tracheal Intubation Morbidity.
What interventions are being tested in trial NCT05451953?
The interventions under investigation include: Standard of Care (PROCEDURE), Apneic Oxygenation (PROCEDURE).
Who is sponsoring clinical trial NCT05451953?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05451953 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05451953's enrollment target sits among peer trials
110 816th of 2000 higher than 1,176 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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