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NCT05449392 · ClinicalTrials.gov registry record · Phase 1
Topical Antibacterial Agents for Prevention of COVID-19
A Phase 1 study, sponsored by Yale University.
- Completed
- Registry status
- Phase 1
- Development phase
- 67
- Enrollment target
NCT05449392: Completed Phase 1 study, sponsored by Yale University.
NCT05449392 is a Phase 1 study that has completed, run by Yale University. The registered enrollment target is 67 participants, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (12% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05449392, a Phase 1 study, has completed, sponsored by Yale University.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 67 participants
- Enrollment target
Study Summary
The primary objective of this study is to determine whether intranasal application of aminoglycoside (Neosporin) increases local nasal innate immune responses compared to placebo control in healthy participants.
Primary Outcome
Measurement of interferon response from samples collected using a multiplex ELISA to detect which interferon-stimulated genes (ISGs) are present in sample. ISGs measured include Irf7, Oas1a, Oasl2, Cxcl9, and CxcL10 as well as other corresponding interferons such as Ifna, ifnb, and ifnl
Interventions
- OTHER Vaseline
- DRUG Neosporin
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 67 participants |
| Start Date | 2022-09-01 |
| Est. Completion | 2023-09-22 |
| Phase | Phase 1 |
What the finished NCT05449392 record still lists
NCT05449392 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 67 participants, a relatively small participant target, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (12% higher).
The record links to 0 conditions, and to 2 interventions - of which Vaseline is the first listed.
NCT05449392 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05449392 about?
NCT05449392 is a clinical study titled "Topical Antibacterial Agents for Prevention of COVID-19". The primary objective of this study is to determine whether intranasal application of aminoglycoside (Neosporin) increases local nasal innate immune responses compared to placebo control in healthy participants.
What is the current status of trial NCT05449392?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 67 participants. The study started on 2022-09-01. Estimated completion is 2023-09-22.
What interventions are being tested in trial NCT05449392?
The interventions under investigation include: Vaseline (OTHER), Neosporin (DRUG).
Who is sponsoring clinical trial NCT05449392?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05449392's enrollment target sits among peer trials
67 782nd of 2000 higher than 1,215 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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