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NCT05449132 · ClinicalTrials.gov registry record · Phase 3
Comparison of a Single RTX-GRT7039 and Placebo Intra-articular Injection for Pain Associated With Osteoarthritis of the Knee
A Phase 3 study, sponsored by Grünenthal.
- Completed
- Registry status
- Phase 3
- Development phase
- 466
- Enrollment target
NCT05449132: Completed Phase 3 study, sponsored by Grünenthal.
NCT05449132 is a Phase 3 study that has completed, run by Grünenthal. The registered enrollment target is 466 participants, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (40% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05449132, a Phase 3 study, has completed, sponsored by Grünenthal.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 466 participants
- Enrollment target
Study Summary
A double-blind, randomized, placebo-controlled, parallel-group, multi-site, clinical trial to confirm the efficacy and safety of single injection of RTX-GRT7039 versus placebo in patients who have pain associated with osteoarthritis of the knee despite standard of care.
Primary Outcome
Difference in mean change from baseline in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale score using an 11-point (0-10) numeric rating scale (NRS) between RTX-GRT7039 and placebo. The WOMAC pain subscale consists of 5 questions using an 11-point numeric rating scale (NRS, from 0 = no pain to 10 = pain as bad as you can imagine). The scores are averaged over the number of questions.
Interventions
- DRUG Placebo
- DRUG RTX-GRT7039
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 466 participants |
| Start Date | 2022-09-26 |
| Est. Completion | 2024-08-15 |
| Phase | Phase 3 |
What the finished NCT05449132 record still lists
NCT05449132 is an interventional study that assigns participants to a tested intervention. The registered 466 participants enrollment target is mid-sized for trials with a published cap, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (40% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT05449132 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05449132 about?
NCT05449132 is a clinical study titled "Comparison of a Single RTX-GRT7039 and Placebo Intra-articular Injection for Pain Associated With Osteoarthritis of the Knee". A double-blind, randomized, placebo-controlled, parallel-group, multi-site, clinical trial to confirm the efficacy and safety of single injection of RTX-GRT7039 versus placebo in patients who have pain associated with osteoarthritis of the knee despite standard of care.
What is the current status of trial NCT05449132?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 466 participants. The study started on 2022-09-26. Estimated completion is 2024-08-15.
What interventions are being tested in trial NCT05449132?
The interventions under investigation include: Placebo (DRUG), RTX-GRT7039 (DRUG).
Who is sponsoring clinical trial NCT05449132?
This trial is sponsored by Grünenthal, which has 16 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05449132's enrollment target sits among peer trials
466 816th of 2000 higher than 1,182 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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