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NCT05429320 · ClinicalTrials.gov registry record · Phase 2
A Study of Local Ablative Therapy (LAT) in People With Non-Small Cell Lung Cancer (NSCLC)
A Phase 2 study, sponsored by Memorial Sloan Kettering Cancer Center.
- Completed
- Registry status
- Phase 2
- Development phase
- 37
- Enrollment target
NCT05429320: Completed Phase 2 study, sponsored by Memorial Sloan Kettering Cancer Center.
NCT05429320 is a Phase 2 study that has completed, run by Memorial Sloan Kettering Cancer Center. The registered enrollment target is 37 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (72% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05429320, a Phase 2 study, has completed, sponsored by Memorial Sloan Kettering Cancer Center.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 37 participants
- Enrollment target
Study Summary
The purpose of this study is to see whether receiving local ablative therapy (LAT) when minimal residual disease/MRD levels are rising can reduce MRD levels and control metastatic non-small cell lung cancer/NSCLC longer compared to systemic therapy.
Primary Outcome
To determine whether Local Ablative Therapy/LAT (ablation to all sites of disease) causes a reduction in mean variant allele frequency/VAF by 6 months after LAT in patients with metastatic NSCLC who have non-responding variant allele frequency/NR-VAF (\<50% reduction in mean VAF) but no radiographic progression of disease. Mean VAF: Mean VAF will be defined by the VAF of each relevant mutation divided by the total number of mutations
Interventions
- PROCEDURE Local ablative therapy
- OTHER Blood collection to assess for ctDNA
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 37 participants |
| Start Date | 2022-06-15 |
| Est. Completion | 2026-01-28 |
| Phase | Phase 2 |
What the finished NCT05429320 record still lists
NCT05429320 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 37 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (72% lower).
The record links to 0 conditions, and to 2 interventions - of which Local ablative therapy is the first listed.
NCT05429320 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05429320 about?
NCT05429320 is a clinical study titled "A Study of Local Ablative Therapy (LAT) in People With Non-Small Cell Lung Cancer (NSCLC)". The purpose of this study is to see whether receiving local ablative therapy (LAT) when minimal residual disease/MRD levels are rising can reduce MRD levels and control metastatic non-small cell lung cancer/NSCLC longer compared to systemic therapy.
What is the current status of trial NCT05429320?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 37 participants. The study started on 2022-06-15. Estimated completion is 2026-01-28.
What interventions are being tested in trial NCT05429320?
The interventions under investigation include: Local ablative therapy (PROCEDURE), Blood collection to assess for ctDNA (OTHER).
Who is sponsoring clinical trial NCT05429320?
This trial is sponsored by Memorial Sloan Kettering Cancer Center, which has 1,884 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05429320's enrollment target sits among peer trials
37 1484th of 2000 higher than 505 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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