Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 1

Study of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid Malignancies

NCT05417594 · View on ClinicalTrials.gov ↗

Study Summary

This study will assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary efficacy of AZD9574 individually and in combination with anti-cancer agents in participants with advanced cancer that has recurred/progressed.

Interventions

  • DRUG AZD9574
  • DRUG Trastuzumab Deruxtecan (T-DXd)
  • DRUG Temozolomide (TMZ)
  • DRUG [11C]AZ1419 3391
  • DRUG Datopotamab Deruxtecan (Dato-DXd)

Study Locations (20)

Other

  • Research Site — Camperdown
  • Research Site — Darlinghurst
  • Research Site — Melbourne
  • Research Site — Randwick
  • Research Site — Bayern
  • Research Site — Berlin
  • Research Site — Heidelberg
  • Research Site — Mainz
  • Research Site — Seoul

California

  • Research Site — La Jolla
  • Research Site — Los Angeles
  • Research Site — San Francisco

New York

  • Research Site — New York
  • Research Site — New York

Texas

  • Research Site — Houston
  • Research Site — San Antonio

Illinois

  • Research Site — Chicago

Massachusetts

  • Research Site — Boston

Oregon

  • Research Site — Portland

Virginia

  • Research Site — Richmond

Trial Details

FieldValue
Enrollment Target 695 participants
Start Date 2022-06-24
Est. Completion 2027-08-11
Phase Phase 1

Sponsor

AstraZeneca

1,053 total trials

Interested in This Trial?

Always speak with your doctor before enrolling in a clinical trial.

Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05417594

The ClinicalTrials.gov registry entry for NCT05417594 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 695 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is AstraZeneca, which has 1,053 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Advanced Solid Malignancies appearing as the primary indexed condition, and to 5 interventions — of which AZD9574 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05417594 reports 20 study locations spanning 8 distinct geographic areas — top geographies include Other, California, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05417594 about?

NCT05417594 is a clinical study titled "Study of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid Malignancies". This study will assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary efficacy of AZD9574 individually and in combination with anti-cancer agents in participants with advanced cancer that has recurred/progressed.

What is the current status of trial NCT05417594?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 695 participants. The study started on 2022-06-24. Estimated completion is 2027-08-11.

What conditions does trial NCT05417594 study?

This clinical trial studies the following conditions: Advanced Solid Malignancies. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05417594?

The interventions under investigation include: AZD9574 (DRUG), Trastuzumab Deruxtecan (T-DXd) (DRUG), Temozolomide (TMZ) (DRUG), [11C]AZ1419 3391 (DRUG), Datopotamab Deruxtecan (Dato-DXd) (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05417594?

This trial is sponsored by AstraZeneca, which has 1,053 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05417594 being conducted?

This trial has 20 study locations across California, Illinois, Massachusetts, New York, Oregon. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial