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NCT05409027 · ClinicalTrials.gov registry record · Phase 1
A Study to Assess 11 Beta-hydroxysteroid Dehydrogenase Type 1 Inhibition in Adipose Tissue by SPI-62
A Phase 1 study, sponsored by Sparrow Pharmaceuticals.
- Completed
- Registry status
- Phase 1
- Development phase
- 12
- Enrollment target
NCT05409027: Completed Phase 1 study, sponsored by Sparrow Pharmaceuticals.
NCT05409027 is a Phase 1 study that has completed, run by Sparrow Pharmaceuticals. The registered enrollment target is 12 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (80% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05409027, a Phase 1 study, has completed, sponsored by Sparrow Pharmaceuticals.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 12 participants
- Enrollment target
Study Summary
This will be an exploratory, open-label study of 11β-hydroxysteroid dehydrogenase type 1 (HSD-1) inhibition by SPI-62 in obese subjects with type 2 diabetes mellitus (T2DM)
Primary Outcome
Pharmacokinetics of SPI-62 and its major metabolite AS2570469 by assessment of Observed Maximum Plasma Concentration (Cmax)
Interventions
- DRUG SPI-62
- DRUG Cortisone-d8
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 12 participants |
| Start Date | 2021-07-23 |
| Est. Completion | 2024-02-07 |
| Phase | Phase 1 |
What the finished NCT05409027 record still lists
NCT05409027 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 12 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (80% lower).
The record links to 0 conditions, and to 2 interventions - of which SPI-62 is the first listed.
NCT05409027 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05409027 about?
NCT05409027 is a clinical study titled "A Study to Assess 11 Beta-hydroxysteroid Dehydrogenase Type 1 Inhibition in Adipose Tissue by SPI-62". This will be an exploratory, open-label study of 11β-hydroxysteroid dehydrogenase type 1 (HSD-1) inhibition by SPI-62 in obese subjects with type 2 diabetes mellitus (T2DM)
What is the current status of trial NCT05409027?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 12 participants. The study started on 2021-07-23. Estimated completion is 2024-02-07.
What interventions are being tested in trial NCT05409027?
The interventions under investigation include: SPI-62 (DRUG), Cortisone-d8 (DRUG).
Who is sponsoring clinical trial NCT05409027?
This trial is sponsored by Sparrow Pharmaceuticals, which has 6 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05409027's enrollment target sits among peer trials
12 1852nd of 2000 higher than 90 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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