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NCT05400863 · ClinicalTrials.gov registry record · NA
Effect of NNS on Metformin/GDF15, Pilot
A NA study, sponsored by University of Florida.
- Completed
- Registry status
- NA
- Development phase
- 46
- Enrollment target
NCT05400863: Completed NA study, sponsored by University of Florida.
NCT05400863 is a NA study that has completed, run by University of Florida. The registered enrollment target is 46 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05400863, a NA study, has completed, sponsored by University of Florida.
- COMPLETED
- Registry status
- NA
- Development phase
- 46 participants
- Enrollment target
Study Summary
Metformin use for diabetes has the benefit of causing weight loss in some. The investigators in a preclinical trial, demonstrated that mice consuming non-nutritive sweetened (NNS) drinks had worse glucose improvements and weight loss than mice consuming sugar drinks or water. This study will conduct a pilot to determine if this translates into pediatric clinical practice. The hypothesis is that NNS drinks impair metformin-induced satiation, weight loss, and glucose tolerance.
Primary Outcome
Compare post-intervention (metformin) body weight between participants randomized to receive education and counseling to either a) avoid all sweetened drinks (drink water only) or b) avoid drinks sweetened with sugar (can have diet drinks sweetened with NNS)
Interventions
- BEHAVIORAL avoid sugary and NNS drinks plus start Metformin
- BEHAVIORAL avoid sugary drinks (allowed water and drinks sweetened with NNS) plus start Metformin
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 46 participants |
| Start Date | 2022-04-21 |
| Est. Completion | 2024-08-02 |
| Phase | NA |
What the finished NCT05400863 record still lists
NCT05400863 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 46 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 2 interventions - of which avoid sugary and NNS drinks plus start Metformin is the first listed.
NCT05400863 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05400863 about?
NCT05400863 is a clinical study titled "Effect of NNS on Metformin/GDF15, Pilot". Metformin use for diabetes has the benefit of causing weight loss in some. The investigators in a preclinical trial, demonstrated that mice consuming non-nutritive sweetened (NNS) drinks had worse glucose improvements and weight loss than mice consuming sugar drinks or water. This study will conduct...
What is the current status of trial NCT05400863?
This trial is currently completed. It is a NA study. The enrollment target is 46 participants. The study started on 2022-04-21. Estimated completion is 2024-08-02.
What interventions are being tested in trial NCT05400863?
The interventions under investigation include: avoid sugary and NNS drinks plus start Metformin (BEHAVIORAL), avoid sugary drinks (allowed water and drinks sweetened with NNS) plus start Metformin (BEHAVIORAL).
Who is sponsoring clinical trial NCT05400863?
This trial is sponsored by University of Florida, which has 1,106 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05400863's enrollment target sits among peer trials
46 1402nd of 2000 higher than 590 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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