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NCT05384496 · ClinicalTrials.gov registry record · Phase 2
Axitinib and Nivolumab for the Treatment of Mucosal Melanoma
A Phase 2 study of Mucosal Melanoma, sponsored by Memorial Sloan Kettering Cancer Center.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 20
- Enrollment target
- 2
- Study locations
NCT05384496: Recruiting Phase 2 study of Mucosal Melanoma, sponsored by Memorial Sloan Kettering Cancer Center.
NCT05384496 is a Phase 2 study of Mucosal Melanoma that is actively recruiting participants, run by Memorial Sloan Kettering Cancer Center. The registered enrollment target is 20 participants, below the 153-participant average among 12 other Mucosal Melanoma trials with a reported enrollment target (87% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05384496, a Phase 2 study of Mucosal Melanoma, is actively recruiting participants, sponsored by Memorial Sloan Kettering Cancer Center.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 20 participants
- Enrollment target
- 2
- Study locations
Study Summary
The researchers are doing this study to find out whether the combination of axitinib and nivolumab is an effective and safe treatment for people with advanced or metastatic mucosal melanoma that has not been treated before. The researchers think that a combination of axitinib and nivolumab may help people with this disease because both drugs target and block proteins that play a role in cancer cell survival and growth. The researchers think the drugs may be more effective if given in combination rather than on their own.
Primary Outcome
by RECIST 1.1.The Response Evaluation Criteria in Solid Tumors (RECIST)
Conditions Studied
Interventions
- DRUG Nivolumab and/or Ipilimumab
- RADIATION Stereotactic Body Radiation Therapy (SBRT)
- DRUG axitinib
Study Locations (2)
New York
- Memorial Sloan Kettering Westchester - Harrison
- Memorial Sloan Kettering Cancer Center - New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2022-05-17 |
| Est. Completion | 2027-05 |
| Phase | Phase 2 |
What NCT05384496 shows while recruiting
NCT05384496 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 153-participant average among 12 other Mucosal Melanoma trials with a reported enrollment target (87% lower).
The record links to 1 condition, with Mucosal Melanoma appearing as the primary indexed condition, and to 3 interventions - of which Nivolumab and/or Ipilimumab is the first listed.
NCT05384496 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT05384496 about?
NCT05384496 is a clinical study titled "Axitinib and Nivolumab for the Treatment of Mucosal Melanoma". The researchers are doing this study to find out whether the combination of axitinib and nivolumab is an effective and safe treatment for people with advanced or metastatic mucosal melanoma that has not been treated before. The researchers think that a combination of axitinib and nivolumab may help...
What is the current status of trial NCT05384496?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 20 participants. The study started on 2022-05-17. Estimated completion is 2027-05.
What conditions does trial NCT05384496 study?
This clinical trial studies the following conditions: Mucosal Melanoma.
What interventions are being tested in trial NCT05384496?
The interventions under investigation include: Nivolumab and/or Ipilimumab (DRUG), Stereotactic Body Radiation Therapy (SBRT) (RADIATION), axitinib (DRUG).
Who is sponsoring clinical trial NCT05384496?
This trial is sponsored by Memorial Sloan Kettering Cancer Center, which has 1,884 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05384496 being conducted?
This trial has 2 study locations across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Mucosal Melanoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05384496's enrollment target sits among peer trials
20 11th of 12 higher than 1 of 12 other Mucosal Melanoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Mucosal Melanoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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