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NCT05379959 · ClinicalTrials.gov registry record · Early Phase 1
Effects of Stimulants on Behavioral and Neural Markers of Social Motivation, Ability, and Neural Markers of Social Function
A Early Phase 1 study, sponsored by University of Chicago.
- Completed
- Registry status
- Early Phase 1
- Development phase
- 43
- Enrollment target
NCT05379959: Completed Early Phase 1 study, sponsored by University of Chicago.
NCT05379959 is a Early Phase 1 study that has completed, run by University of Chicago. The registered enrollment target is 43 participants, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (19% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05379959, a Early Phase 1 study, has completed, sponsored by University of Chicago.
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 43 participants
- Enrollment target
Study Summary
To study the effects of MDMA, compared to a prototypical stimulant, on social motivation, social ability, and neural indices of social function in healthy volunteers
Primary Outcome
The POMS measures individuals' mood states. This is a validated scale to measure positive and negative mood states. The POMS contains 30 items and assesses six identified mood factors: Tension-Anxiety, Depression-Ejection, Anger- Hostility, Vigor-Activity, Fatigue-Inertia, and Confusion-Bewilderment. Scoring of the instrument provides a global score of 0 to 120 or individual domain scores. Lower scores indicate better mood state. The POMS brief form is a simple self-rating instrument.
Interventions
- DRUG Methamphetamine
- DRUG MDMA
- DRUG placebo oral tablet
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 43 participants |
| Start Date | 2022-05-11 |
| Est. Completion | 2023-10-24 |
| Phase | Early Phase 1 |
What the finished NCT05379959 record still lists
NCT05379959 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 43 participants, a relatively small participant target, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (19% lower).
The record links to 0 conditions, and to 3 interventions - of which Methamphetamine is the first listed.
NCT05379959 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05379959 about?
NCT05379959 is a clinical study titled "Effects of Stimulants on Behavioral and Neural Markers of Social Motivation, Ability, and Neural Markers of Social Function". To study the effects of MDMA, compared to a prototypical stimulant, on social motivation, social ability, and neural indices of social function in healthy volunteers
What is the current status of trial NCT05379959?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 43 participants. The study started on 2022-05-11. Estimated completion is 2023-10-24.
What interventions are being tested in trial NCT05379959?
The interventions under investigation include: Methamphetamine (DRUG), MDMA (DRUG), placebo oral tablet (DRUG).
Who is sponsoring clinical trial NCT05379959?
This trial is sponsored by University of Chicago, which has 796 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05379959's enrollment target sits among peer trials
43 600th of 2000 higher than 1,397 of 2,000 other Early Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Early Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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