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NCT05377554 · ClinicalTrials.gov registry record · Phase 3
Bevonescein for Intra-Operative Nerve Visualization in Head and Neck Surgery
A Phase 3 study, sponsored by Alume Biosciences.
- Completed
- Registry status
- Phase 3
- Development phase
- 154
- Enrollment target
NCT05377554: Completed Phase 3 study, sponsored by Alume Biosciences.
NCT05377554 is a Phase 3 study that has completed, run by Alume Biosciences. The registered enrollment target is 154 participants, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (80% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05377554, a Phase 3 study, has completed, sponsored by Alume Biosciences.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 154 participants
- Enrollment target
Study Summary
This protocol describes prospective, open-label, blinded, randomized controlled, multicenter pivotal studies to evaluate bevonescein.
Primary Outcome
Nerve Conspicuity will be compared between WLR and WLR with FL Overlay Using the Visualization Scoring System.
Interventions
- DRUG Bevonescein
- OTHER Intraoperative Visualization using White Light Reflectance (WLR) with Fluorescence (FL) Overlay
- OTHER Intra-operative Visualization using White Light Reflectance (WLR)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 154 participants |
| Start Date | 2022-04-29 |
| Est. Completion | 2025-11-24 |
| Phase | Phase 3 |
What the finished NCT05377554 record still lists
NCT05377554 is an interventional study that assigns participants to a tested intervention. The registered 154 participants enrollment target is mid-sized for trials with a published cap, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (80% lower).
The record links to 0 conditions, and to 3 interventions - of which Bevonescein is the first listed.
NCT05377554 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05377554 about?
NCT05377554 is a clinical study titled "Bevonescein for Intra-Operative Nerve Visualization in Head and Neck Surgery". This protocol describes prospective, open-label, blinded, randomized controlled, multicenter pivotal studies to evaluate bevonescein.
What is the current status of trial NCT05377554?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 154 participants. The study started on 2022-04-29. Estimated completion is 2025-11-24.
What interventions are being tested in trial NCT05377554?
The interventions under investigation include: Bevonescein (DRUG), Intraoperative Visualization using White Light Reflectance (WLR) with Fluorescence (FL) Overlay (OTHER), Intra-operative Visualization using White Light Reflectance (WLR) (OTHER).
Who is sponsoring clinical trial NCT05377554?
This trial is sponsored by Alume Biosciences, which has 4 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05377554's enrollment target sits among peer trials
154 1509th of 2000 higher than 491 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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