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NCT05363683 · ClinicalTrials.gov registry record · NA
Optimizing Movement After Anterior Cruciate Ligament Injury
A NA study, sponsored by University of Nebraska.
- Completed
- Registry status
- NA
- Development phase
- 34
- Enrollment target
NCT05363683 is a NA study that has completed, run by University of Nebraska. The registered enrollment target is 34 participants.
The verdict
NCT05363683, a NA study, has completed, sponsored by University of Nebraska.
- COMPLETED
- Registry status
- NA
- Development phase
- 34 participants
- Enrollment target
Study Summary
Fifty percent of teenagers and young adults who suffer an anterior cruciate ligament (ACL) injury develop knee osteoarthritis (OA) within 15 years. The resulting pain, reduced quality-of-life, and increased risk for co-morbidity lead to substantial healthcare costs, inability to fulfill work and personal responsibilities, and reduced long-term health. Degeneration in articular cartilage, connective tissue that covers the ends of bones in the knee, is the hallmark of early OA development after knee injury. This deterioration can be measured by an imaging biomarker for OA development on quantitative magnetic resonance imaging (MRI). Harmful increases in MRI markers of the knee's articular cartilage occur within months of ACL injury and indicate preventative interventions should begin soon after injury. However, evidence-based interventions to prevent OA do not exist. This project will challenge the traditional OA paradigm that too much joint loading (e.g. "wear and tear") causes cartilage breakdown. A multi-disciplinary team has developed a novel visual biofeedback paradigm using portable force plates that can increase knee loading during squats within a single session after ACL reconstruction (ACLR). This study will determine the efficacy of the visual biofeedback program initiated two weeks after ACLR by assessing movement biomechanics and MRI changes in cartilage after six months later. Successful completion of this project will establish the first rehabilitation intervention to effectively and optimally load the knee joint early after ACLR, providing the initial steps to prevent OA after ACL injury.
Interventions
- PROCEDURE Squat Biofeedback
- PROCEDURE Standard Care
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 34 participants |
| Start Date | 2021-11-11 |
| Est. Completion | 2024-06-05 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05363683
The ClinicalTrials.gov registry entry for NCT05363683 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 34 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Nebraska, which has 407 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Squat Biofeedback is the first listed.
NCT05363683 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT05363683 about?
NCT05363683 is a clinical study titled "Optimizing Movement After Anterior Cruciate Ligament Injury". Fifty percent of teenagers and young adults who suffer an anterior cruciate ligament (ACL) injury develop knee osteoarthritis (OA) within 15 years. The resulting pain, reduced quality-of-life, and increased risk for co-morbidity lead to substantial healthcare costs, inability to fulfill work and per...
What is the current status of trial NCT05363683?
This trial is currently completed. It is a NA study. The enrollment target is 34 participants. The study started on 2021-11-11. Estimated completion is 2024-06-05.
What interventions are being tested in trial NCT05363683?
The interventions under investigation include: Squat Biofeedback (PROCEDURE), Standard Care (PROCEDURE).
Who is sponsoring clinical trial NCT05363683?
This trial is sponsored by University of Nebraska, which has 407 total clinical trials registered on ClinicalTrials.gov.
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