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NCT05335928 · ClinicalTrials.gov registry record · Phase 3
Abatacept in Immune Checkpoint Inhibitor Myocarditis
A Phase 3 study of Cancer and Myocarditis Acute, sponsored by Massachusetts General Hospital.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 390
- Enrollment target
- 20
- Study locations
NCT05335928 is a Phase 3 study of Cancer and Myocarditis Acute that is actively recruiting participants, run by Massachusetts General Hospital. The registered enrollment target is 390 participants, below the 3,490-participant average among 615 other Cancer trials with a reported enrollment target (89% lower). The trial reports 20 study locations across 15 states.
The verdict
NCT05335928, a Phase 3 study of Cancer and Myocarditis Acute, is actively recruiting participants, sponsored by Massachusetts General Hospital.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 390 participants
- Enrollment target
- 20
- Study locations
Study Summary
The primary aim is to test whether abatacept, as compared to placebo, is associated with a reduction in major adverse cardiac events (MACE) among participants hospitalized with myocarditis secondary to an immune checkpoint inhibitor (ICI). The primary outcome, MACE, is a composite of first occurrence of cardiovascular death, non-fatal sudden cardiac arrest, cardiogenic shock, significant ventricular arrythmias, significant bradyarrythmias, or incident heart failure.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Abatacept plus
Study Locations (20)
Massachusetts
- Massachusetts General Hospital - Boston
- Beth Israel Deaconess Medical Center - Boston
- Boston Medical Center - Boston
- Brigham and Women's Hospital - Boston
California
- Cedars-Sinai Medical Center - Los Angeles
- University of California Los Angeles - Los Angeles
New York
- Columbia University Irving Medical Center - New York
- Memorial Sloan Kettering Cancer Center - New York
District of Columbia
- MedStar Health Research Institute, Georgetown University - Washington D.C.
Florida
- Moffitt Cancer Center - Tampa
Illinois
- University of Chicago - Chicago
Indiana
- Franciscan Health - Indianapolis
Kansas
- University of Kansas Medical Center - Kansas City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 390 participants |
| Start Date | 2022-07-02 |
| Est. Completion | 2027-04-20 |
| Phase | Phase 3 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05335928
The ClinicalTrials.gov registry entry for NCT05335928 describes a study currently listed as recruiting, categorized as Phase 3. The registered enrollment target is 390 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 3,490-participant average among 615 other Cancer trials with a reported enrollment target (89% lower). The listed sponsor is Massachusetts General Hospital, which has 2,032 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Cancer appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT05335928 reports 20 study locations spanning 15 distinct geographic areas - top geographies include Massachusetts, California, New York.
Frequently Asked Questions
What is clinical trial NCT05335928 about?
NCT05335928 is a clinical study titled "Abatacept in Immune Checkpoint Inhibitor Myocarditis". The primary aim is to test whether abatacept, as compared to placebo, is associated with a reduction in major adverse cardiac events (MACE) among participants hospitalized with myocarditis secondary to an immune checkpoint inhibitor (ICI). The primary outcome, MACE, is a composite of first occurrenc...
What is the current status of trial NCT05335928?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 390 participants. The study started on 2022-07-02. Estimated completion is 2027-04-20.
What conditions does trial NCT05335928 study?
This clinical trial studies the following conditions: Cancer, Myocarditis Acute.
What interventions are being tested in trial NCT05335928?
The interventions under investigation include: Placebo (DRUG), Abatacept plus (DRUG).
Who is sponsoring clinical trial NCT05335928?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05335928 being conducted?
This trial has 20 study locations across California, District of Columbia, Florida, Illinois, Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.