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NCT05332912 · ClinicalTrials.gov registry record · NA

Assessing Malleability of Spatial Abilities in Down Syndrome

A NA study, sponsored by University of Alabama, Tuscaloosa.

Completed
Registry status
NA
Development phase
84
Enrollment target

NCT05332912: Completed NA study, sponsored by University of Alabama, Tuscaloosa.

NCT05332912 is a NA study that has completed, run by University of Alabama, Tuscaloosa. The registered enrollment target is 84 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (94% lower). According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT05332912, a NA study, has completed, sponsored by University of Alabama, Tuscaloosa.

COMPLETED
Registry status
NA
Development phase
84 participants
Enrollment target

Study Summary

Based on available literature and our own preliminary research, the researchers have concluded that persons with Down syndrome (DS) exhibit difficulties in utilizing the specific spatial abilities of mental rotation and perspective taking and performing complex spatial tasks such as wayfinding and environmental learning. A weakness in spatial abilities may have many direct applications to daily life, ranging from activities such as tying shoes to using hand tools and navigating the environment. Spatial abilities also serve as a cognitive foundation for many other complex skills such as solving mathematical problems and using spatial language for giving and receiving directions. Moreover, spatial abilities are used in a variety of specialty jobs such as grocery stocking, packaging, and assembling, which are among the most commonly reported jobs for adults with DS. Hence, a new focus on spatial ability and its modifiability in persons with DS is clearly warranted. The primary goal of the research proposed in this application is to evaluate the malleability of mental rotation and perspective taking in people with DS through providing intentional experience with numerous spatial activities. Two groups of participants will be tested over the course of the project: adolescents and young adults with DS and typically developing (TD) children. Following an initial evaluation of performance on the two abilities, participants will receive up to eight sessions of spatial activity experience utilizing puzzle construction, block building, and computer search tasks. Following the experience sessions, spatial abilities of participants will be re-evaluated. These data will be used to investigate two specific aims. First, the researchers investigate whether spatial abilities of persons with DS can be modified by experience with spatial activities. Second, the researchers investigate whether the degree of modification observed for persons with DS can reduce performance differences bet

Primary Outcome

The Mental Rotation Assessment was used to assess ability to match objects rotated at varying degrees from a standard. Number of correct matches out of 18 possible matches over all rotations (excluding 0 degrees) was used as a measure of performance. Minimum score = 0. Maximum score = 18. Higher scores reflect better performance. Change in Mental Rotation Ability was calculated by subtracting Baseline (Time 1) Assessment scores from 8 Week (Time 2) Assessment scores.

Interventions

  • BEHAVIORAL Spatial Ability Experience

Trial Details

FieldValue
Enrollment Target 84 participants
Start Date 2021-04-01
Est. Completion 2025-03-31
Phase NA
University of Alabama, Tuscaloosa

13 total trials

What the finished NCT05332912 record still lists

NCT05332912 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 84 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (94% lower).

The record links to 0 conditions, and to 1 intervention - of which Spatial Ability Experience is the first listed.

NCT05332912 does not publish any study locations in the registry export this page uses.

Frequently Asked Questions

What is clinical trial NCT05332912 about?

NCT05332912 is a clinical study titled "Assessing Malleability of Spatial Abilities in Down Syndrome". Based on available literature and our own preliminary research, the researchers have concluded that persons with Down syndrome (DS) exhibit difficulties in utilizing the specific spatial abilities of mental rotation and perspective taking and performing complex spatial tasks such as wayfinding and e...

What is the current status of trial NCT05332912?

This trial is currently completed. It is a NA study. The enrollment target is 84 participants. The study started on 2021-04-01. Estimated completion is 2025-03-31.

What interventions are being tested in trial NCT05332912?

The interventions under investigation include: Spatial Ability Experience (BEHAVIORAL).

Who is sponsoring clinical trial NCT05332912?

This trial is sponsored by University of Alabama, Tuscaloosa, which has 13 total clinical trials registered on ClinicalTrials.gov.

How this trial's enrollment target compares

Where NCT05332912's enrollment target sits among peer trials

84 983rd of 2000 higher than 1,011 of 2,000 other NA trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Source: ClinicalTrials.gov NCT05332912, the US trial registry maintained by the National Library of Medicine. NCT05332912 (small enrollment · none site footprint · completed) retrieved and formatted by PlainTrial, see methodology.