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NCT05327556 · ClinicalTrials.gov registry record · Phase 2
Epinephrine in the Pediatric Intensive Care Unit: A Dose-Effect Trial
A Phase 2 study, sponsored by Boston Children's Hospital.
- Terminated
- Registry status
- Phase 2
- Development phase
- 15
- Enrollment target
NCT05327556 is a Phase 2 study that was terminated before completion, run by Boston Children's Hospital. The registered enrollment target is 15 participants.
The verdict
NCT05327556, a Phase 2 study, was terminated before completion, sponsored by Boston Children's Hospital.
- TERMINATED
- Registry status
- Phase 2
- Development phase
- 15 participants
- Enrollment target
Study Summary
The use of peri-arrest bolus epinephrine (PBE) has emerged as a rescue strategy for life-threatening hypotension in pediatric intensive care units (ICU) despite scant published data supporting its use in this setting. As optimal dosing of PBE in this population is unclear, we aim to determine if an initial dose of 0.5 mcg/kg versus 1.0 mcg/kg yields differences in hemodynamic outcomes. The EPI Dose Study is a single-center, prospective, randomized, double-blind, dose-effect trial measuring systolic blood pressure (SBP) before and after PBE is given. We hypothesize that the 1.0 mcg/kg group will have more robust increases in SBP.
Interventions
- DRUG Epinephrine 0.5 mcg/kg
- DRUG Epinephrine 1 mcg/kg
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2023-02-08 |
| Est. Completion | 2025-05-16 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05327556
The ClinicalTrials.gov registry entry for NCT05327556 describes a study currently listed as terminated, categorized as Phase 2. The registered enrollment target is 15 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Boston Children's Hospital, which has 462 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Epinephrine 0.5 mcg/kg is the first listed.
NCT05327556 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT05327556 about?
NCT05327556 is a clinical study titled "Epinephrine in the Pediatric Intensive Care Unit: A Dose-Effect Trial". The use of peri-arrest bolus epinephrine (PBE) has emerged as a rescue strategy for life-threatening hypotension in pediatric intensive care units (ICU) despite scant published data supporting its use in this setting. As optimal dosing of PBE in this population is unclear, we aim to determine if an ...
What is the current status of trial NCT05327556?
This trial is currently terminated. It is a Phase 2 study. The enrollment target is 15 participants. The study started on 2023-02-08. Estimated completion is 2025-05-16.
What interventions are being tested in trial NCT05327556?
The interventions under investigation include: Epinephrine 0.5 mcg/kg (DRUG), Epinephrine 1 mcg/kg (DRUG).
Who is sponsoring clinical trial NCT05327556?
This trial is sponsored by Boston Children's Hospital, which has 462 total clinical trials registered on ClinicalTrials.gov.
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