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NCT05279898 · ClinicalTrials.gov registry record · NA
Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies
A NA study, sponsored by Beth Israel Deaconess Medical Center.
- Completed
- Registry status
- NA
- Development phase
- 70
- Enrollment target
NCT05279898: Completed NA study, sponsored by Beth Israel Deaconess Medical Center.
NCT05279898 is a NA study that has completed, run by Beth Israel Deaconess Medical Center. The registered enrollment target is 70 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05279898, a NA study, has completed, sponsored by Beth Israel Deaconess Medical Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 70 participants
- Enrollment target
Study Summary
In the PATHFINDER 2 trial, the study investigators will test the intraoperative EEG-guided multimodal general anesthesia (MMGA) management strategy in combination with a postoperative protocolized analgesic approach to: 1. reduce the incidence of perioperative neurocognitive dysfunction in cardiac surgical patients 2. ensure hemodynamic stability and decrease use of vasopressors in the operating rooms 3. reduce pain and opioid consumption postoperatively
Primary Outcome
Plasma interleukin-6 (IL-6) levels will be measured at baseline, postoperative day 1, and postoperative day 2. The change in IL-6 concentration from baseline to each postoperative time point will be calculated and compared between the study groups.
Interventions
- DRUG Ketamine
- DRUG Dexmedetomidine
- DRUG Ropivacaine
- DRUG Remifentanil
- DEVICE EEG Monitoring
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 70 participants |
| Start Date | 2023-02-28 |
| Est. Completion | 2024-12-31 |
| Phase | NA |
What the finished NCT05279898 record still lists
NCT05279898 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 70 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower).
The record links to 0 conditions, and to 5 interventions - of which Ketamine is the first listed.
NCT05279898 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05279898 about?
NCT05279898 is a clinical study titled "Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies". In the PATHFINDER 2 trial, the study investigators will test the intraoperative EEG-guided multimodal general anesthesia (MMGA) management strategy in combination with a postoperative protocolized analgesic approach to: 1. reduce the incidence of perioperative neurocognitive dysfunction in cardiac ...
What is the current status of trial NCT05279898?
This trial is currently completed. It is a NA study. The enrollment target is 70 participants. The study started on 2023-02-28. Estimated completion is 2024-12-31.
What interventions are being tested in trial NCT05279898?
The interventions under investigation include: Ketamine (DRUG), Dexmedetomidine (DRUG), Ropivacaine (DRUG), Remifentanil (DRUG), EEG Monitoring (DEVICE).
Who is sponsoring clinical trial NCT05279898?
This trial is sponsored by Beth Israel Deaconess Medical Center, which has 488 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05279898's enrollment target sits among peer trials
70 1103rd of 2000 higher than 868 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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