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NCT05263895 · ClinicalTrials.gov registry record · Phase 1
Relative Bioavailability Study of 4 Different Formulations of PF-07321332 Relative to the Commercial Tablet Formulation
A Phase 1 study of Bioavailability, sponsored by Pfizer.
- Completed
- Registry status
- Phase 1
- Development phase
- 12
- Enrollment target
- 1
- Study location
NCT05263895: Completed Phase 1 study of Bioavailability, sponsored by Pfizer.
NCT05263895 is a Phase 1 study of Bioavailability that has completed, run by Pfizer. The registered enrollment target is 12 participants, below the 37-participant average among 8 other Bioavailability trials with a reported enrollment target (68% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05263895, a Phase 1 study of Bioavailability, has completed, sponsored by Pfizer.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 12 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to estimate the relative bioavailability of PF-07321332 in different formulations in healthy adult participants.
Primary Outcome
AUClast for nirmatrelvir was calculated by Linear/Log trapezoidal method. Natural log-transformed AUClast for nirmatrelvir (slower dissolution tablets and large particle size tablets) was analyzed using a mixed effect model with sequence, period and treatment as fixed effects and participant within sequence as a random effect. Natural log-transformed AUClast for Nirmatrelvir (SDD suspension) was analyzed using a mixed effect model with sequence and treatment as fixed effects and participant with
Conditions Studied
Interventions
- DRUG PF-07321332
- DRUG PF-07321332/ritonavir
Study Locations (1)
Connecticut
- Pfizer Clinical Research Unit - New Haven - New Haven
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 12 participants |
| Start Date | 2022-03-03 |
| Est. Completion | 2022-05-16 |
| Phase | Phase 1 |
What the finished NCT05263895 record still lists
NCT05263895 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 12 participants, a relatively small participant target, below the 37-participant average among 8 other Bioavailability trials with a reported enrollment target (68% lower).
The record links to 1 condition, with Bioavailability appearing as the primary indexed condition, and to 2 interventions - of which PF-07321332 is the first listed.
NCT05263895 reports a single indexed study location in Connecticut.
Frequently Asked Questions
What is clinical trial NCT05263895 about?
NCT05263895 is a clinical study titled "Relative Bioavailability Study of 4 Different Formulations of PF-07321332 Relative to the Commercial Tablet Formulation". The purpose of this study is to estimate the relative bioavailability of PF-07321332 in different formulations in healthy adult participants.
What is the current status of trial NCT05263895?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 12 participants. The study started on 2022-03-03. Estimated completion is 2022-05-16.
What conditions does trial NCT05263895 study?
This clinical trial studies the following conditions: Bioavailability.
What interventions are being tested in trial NCT05263895?
The interventions under investigation include: PF-07321332 (DRUG), PF-07321332/ritonavir (DRUG).
Who is sponsoring clinical trial NCT05263895?
This trial is sponsored by Pfizer, which has 1,845 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05263895 being conducted?
This trial has 1 study location across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT05263895's enrollment target sits among peer trials
12 8th of 8 the lowest of 8 other Bioavailability trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Bioavailability trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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